Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

An aged circulatory environment can activate microglia, reduce neural precursor cell activity, and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate at least some of these effects. We observe BECs in the aged mouse hippocampus express an inflammatory transcription...

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Detalles Bibliográficos
Autores principales: Yousef, Hanadie, Czupalla, Cathrin J., Lee, Davis, Chen, Michelle B., Burke, Ashley N., Zera, Kristy A., Zandstra, Judith, Berber, Elisabeth, Lehallier, Benoit, Mathur, Vidhu, Nair, Ramesh V., Bonanno, Liana N., Yang, Andrew C., Peterson, Todd, Hadeiba, Husein, Merkel, Taylor, Körbelin, Jakob, Schwaninger, Markus, Buckwalter, Marion S., Quake, Stephen R., Butcher, Eugene C., Wyss-Coray, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642642/
https://www.ncbi.nlm.nih.gov/pubmed/31086348
http://dx.doi.org/10.1038/s41591-019-0440-4

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