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Osteoarthritis patients with high haemoglobin A1c have increased Toll-like receptor 4 and matrix metalloprotease-13 expression in the synovium

PURPOSE: While research has identified diabetes mellitus (DM) as a risk factor for knee osteoarthritis (KOA), the underlying mechanisms are not fully understood. Studies suggest that Toll-like receptor 4 (TLR4) expression is elevated in osteoarthritic lesions of OA patients and in target tissues of...

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Detalles Bibliográficos
Autores principales:	Murata, Kosuke, Uchida, Kentaro, Takano, Shotaro, Shoji, Shintaro, Iwase, Dai, Inoue, Gen, Aikawa, Jun, Yokozeki, Yuji, Sekiguchi, Hiroyuki, Takaso, Masashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642645/ https://www.ncbi.nlm.nih.gov/pubmed/31406471 http://dx.doi.org/10.2147/DMSO.S209677

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