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Altered differentiation is central to HIV-specific CD4(+) T cell dysfunction in progressive disease

Dysfunction of virus-specific CD4(+) T cells in chronic human infections is poorly understood. We performed genome-wide transcriptional analyses and functional assays of CD4(+) T cells specific for human immunodeficiency virus (HIV) from HIV-infected people prior and after initiation of antiretrovir...

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Detalles Bibliográficos
Autores principales:	Morou, Antigoni, Brunet-Ratnasingham, Elsa, Dubé, Mathieu, Charlebois, Roxanne, Mercier, Eloi, Darko, Sam, Brassard, Nathalie, Nganou-Makamdop, Krystelle, Arumugam, Sahaana, Gendron-Lepage, Gabrielle, Yang, Lifei, Niessl, Julia, Baxter, Amy E., Billingsley, James M., Rajakumar, Premeela A., Lefebvre, François, Johnson, R. Paul, Tremblay, Cécile, Routy, Jean-Pierre, Wyatt, Richard T., Finzi, Andrés, Douek, Daniel C., Kaufmann, Daniel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642691/ https://www.ncbi.nlm.nih.gov/pubmed/31308541 http://dx.doi.org/10.1038/s41590-019-0418-x

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