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Multiple Roles of Exosomal Long Noncoding RNAs in Cancers
Long noncoding RNAs (lncRNAs) are not transcriptional noise, as previously understood, but are currently considered to be multifunctional. Exosomes are derived from the internal multivesicular compartment and are extracellular vesicles (EVs) with diameters of 30–100 nm. Exosomes play significant rol...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642753/ https://www.ncbi.nlm.nih.gov/pubmed/31360701 http://dx.doi.org/10.1155/2019/1460572 |
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author | Zhao, Wenyuan Liu, Yuanqi Zhang, Chunfang Duan, Chaojun |
author_facet | Zhao, Wenyuan Liu, Yuanqi Zhang, Chunfang Duan, Chaojun |
author_sort | Zhao, Wenyuan |
collection | PubMed |
description | Long noncoding RNAs (lncRNAs) are not transcriptional noise, as previously understood, but are currently considered to be multifunctional. Exosomes are derived from the internal multivesicular compartment and are extracellular vesicles (EVs) with diameters of 30–100 nm. Exosomes play significant roles in the intercellular exchange of information and material. Exosomal lncRNAs may be promising biomarkers for cancer diagnosis and potential targets for cancer therapies, since they are increasingly understood to be involved in tumorigenesis, tumor angiogenesis, and chemoresistance. This review mainly focuses on the roles of emerging exosomal lncRNAs in cancer. In addition, the biogenesis of exosomes, the functions of lncRNAs, and the mechanisms of lncRNAs in exosome-mediated cell-cell communication are also summarized. |
format | Online Article Text |
id | pubmed-6642753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-66427532019-07-29 Multiple Roles of Exosomal Long Noncoding RNAs in Cancers Zhao, Wenyuan Liu, Yuanqi Zhang, Chunfang Duan, Chaojun Biomed Res Int Review Article Long noncoding RNAs (lncRNAs) are not transcriptional noise, as previously understood, but are currently considered to be multifunctional. Exosomes are derived from the internal multivesicular compartment and are extracellular vesicles (EVs) with diameters of 30–100 nm. Exosomes play significant roles in the intercellular exchange of information and material. Exosomal lncRNAs may be promising biomarkers for cancer diagnosis and potential targets for cancer therapies, since they are increasingly understood to be involved in tumorigenesis, tumor angiogenesis, and chemoresistance. This review mainly focuses on the roles of emerging exosomal lncRNAs in cancer. In addition, the biogenesis of exosomes, the functions of lncRNAs, and the mechanisms of lncRNAs in exosome-mediated cell-cell communication are also summarized. Hindawi 2019-07-07 /pmc/articles/PMC6642753/ /pubmed/31360701 http://dx.doi.org/10.1155/2019/1460572 Text en Copyright © 2019 Wenyuan Zhao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhao, Wenyuan Liu, Yuanqi Zhang, Chunfang Duan, Chaojun Multiple Roles of Exosomal Long Noncoding RNAs in Cancers |
title | Multiple Roles of Exosomal Long Noncoding RNAs in Cancers |
title_full | Multiple Roles of Exosomal Long Noncoding RNAs in Cancers |
title_fullStr | Multiple Roles of Exosomal Long Noncoding RNAs in Cancers |
title_full_unstemmed | Multiple Roles of Exosomal Long Noncoding RNAs in Cancers |
title_short | Multiple Roles of Exosomal Long Noncoding RNAs in Cancers |
title_sort | multiple roles of exosomal long noncoding rnas in cancers |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642753/ https://www.ncbi.nlm.nih.gov/pubmed/31360701 http://dx.doi.org/10.1155/2019/1460572 |
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