Cargando…

Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a form of arthritis that can lead to fusion of vertebrae and sacroiliac joints following syndesmophyte formation. The etiology of this painful disease remains poorly defined due to its complex genetic background. There are no commonly accepted methods for early diagnos...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Chong, Rong, Tianhua, Li, Zheng, Shen, Jianxiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642776/
https://www.ncbi.nlm.nih.gov/pubmed/31360722
http://dx.doi.org/10.1155/2019/6920281
_version_ 1783437037279379456
author Chen, Chong
Rong, Tianhua
Li, Zheng
Shen, Jianxiong
author_facet Chen, Chong
Rong, Tianhua
Li, Zheng
Shen, Jianxiong
author_sort Chen, Chong
collection PubMed
description Ankylosing spondylitis (AS) is a form of arthritis that can lead to fusion of vertebrae and sacroiliac joints following syndesmophyte formation. The etiology of this painful disease remains poorly defined due to its complex genetic background. There are no commonly accepted methods for early diagnosis of AS, nor are there any effective or efficient clinical treatments. Several noncoding RNAs (ncRNAs) have been linked to AS pathogenesis and inflammation via selective binding of their downstream targets. However, major gaps in knowledge remain to be filled before such findings can be translated into clinical treatments for AS. In this review, we outline recent findings that demonstrate essential roles of ncRNAs in AS mediated via multiple signaling pathways such as the Wnt, transforming growth factor-β/bone morphogenetic protein, inflammatory, T-cell prosurvival, and nuclear factor-κB pathways. The summary of these findings provides insight into the molecular mechanisms by which ncRNAs can be targeted for AS diagnosis and the development of therapeutic drugs against a variety of autoimmune diseases.
format Online
Article
Text
id pubmed-6642776
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-66427762019-07-29 Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis Chen, Chong Rong, Tianhua Li, Zheng Shen, Jianxiong Biomed Res Int Review Article Ankylosing spondylitis (AS) is a form of arthritis that can lead to fusion of vertebrae and sacroiliac joints following syndesmophyte formation. The etiology of this painful disease remains poorly defined due to its complex genetic background. There are no commonly accepted methods for early diagnosis of AS, nor are there any effective or efficient clinical treatments. Several noncoding RNAs (ncRNAs) have been linked to AS pathogenesis and inflammation via selective binding of their downstream targets. However, major gaps in knowledge remain to be filled before such findings can be translated into clinical treatments for AS. In this review, we outline recent findings that demonstrate essential roles of ncRNAs in AS mediated via multiple signaling pathways such as the Wnt, transforming growth factor-β/bone morphogenetic protein, inflammatory, T-cell prosurvival, and nuclear factor-κB pathways. The summary of these findings provides insight into the molecular mechanisms by which ncRNAs can be targeted for AS diagnosis and the development of therapeutic drugs against a variety of autoimmune diseases. Hindawi 2019-07-07 /pmc/articles/PMC6642776/ /pubmed/31360722 http://dx.doi.org/10.1155/2019/6920281 Text en Copyright © 2019 Chong Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chen, Chong
Rong, Tianhua
Li, Zheng
Shen, Jianxiong
Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis
title Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis
title_full Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis
title_fullStr Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis
title_full_unstemmed Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis
title_short Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis
title_sort noncoding rnas involved in the pathogenesis of ankylosing spondylitis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642776/
https://www.ncbi.nlm.nih.gov/pubmed/31360722
http://dx.doi.org/10.1155/2019/6920281
work_keys_str_mv AT chenchong noncodingrnasinvolvedinthepathogenesisofankylosingspondylitis
AT rongtianhua noncodingrnasinvolvedinthepathogenesisofankylosingspondylitis
AT lizheng noncodingrnasinvolvedinthepathogenesisofankylosingspondylitis
AT shenjianxiong noncodingrnasinvolvedinthepathogenesisofankylosingspondylitis