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Type 2 diabetes is associated with the accumulation of senescent T cells
Type 2 diabetes is a global health priority, given that it is driven, in part, by an ageing population, the role of immune senescence has been overlooked. This is surprising, as the functional impairments of senescent T cells show strong similarities to patients with hyperglycaemia. Immune senescenc...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642873/ https://www.ncbi.nlm.nih.gov/pubmed/31251396 http://dx.doi.org/10.1111/cei.13344 |
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author | Lau, E. Y. M. Carroll, E. C. Callender, L. A. Hood, G. A. Berryman, V. Pattrick, M. Finer, S. Hitman, G. A. Ackland, G. L. Henson, S. M. |
author_facet | Lau, E. Y. M. Carroll, E. C. Callender, L. A. Hood, G. A. Berryman, V. Pattrick, M. Finer, S. Hitman, G. A. Ackland, G. L. Henson, S. M. |
author_sort | Lau, E. Y. M. |
collection | PubMed |
description | Type 2 diabetes is a global health priority, given that it is driven, in part, by an ageing population, the role of immune senescence has been overlooked. This is surprising, as the functional impairments of senescent T cells show strong similarities to patients with hyperglycaemia. Immune senescence is typified by alterations in T cell memory, such as the accumulation of highly differentiated end‐stage memory T cells, as well as a constitutive low‐grade inflammation, which drives further immune differentiation. We show here in a preliminary study that people living with type 2 diabetes have a higher circulating volume of senescent T cells accompanied with a higher level of systemic inflammation. This inflammatory environment drives the expression of a unique array of chemokine receptors on senescent T cells, most notably C‐X‐C motif chemokine receptor type 2. However, this increased expression of migratory markers does not translate to improved extravasation owing to a lack of glucose uptake by the T cells. Our results therefore demonstrate that the presence of senescent T cells has a detrimental impact on immune function during type 2 diabetes. |
format | Online Article Text |
id | pubmed-6642873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66428732019-07-30 Type 2 diabetes is associated with the accumulation of senescent T cells Lau, E. Y. M. Carroll, E. C. Callender, L. A. Hood, G. A. Berryman, V. Pattrick, M. Finer, S. Hitman, G. A. Ackland, G. L. Henson, S. M. Clin Exp Immunol Original Articles Type 2 diabetes is a global health priority, given that it is driven, in part, by an ageing population, the role of immune senescence has been overlooked. This is surprising, as the functional impairments of senescent T cells show strong similarities to patients with hyperglycaemia. Immune senescence is typified by alterations in T cell memory, such as the accumulation of highly differentiated end‐stage memory T cells, as well as a constitutive low‐grade inflammation, which drives further immune differentiation. We show here in a preliminary study that people living with type 2 diabetes have a higher circulating volume of senescent T cells accompanied with a higher level of systemic inflammation. This inflammatory environment drives the expression of a unique array of chemokine receptors on senescent T cells, most notably C‐X‐C motif chemokine receptor type 2. However, this increased expression of migratory markers does not translate to improved extravasation owing to a lack of glucose uptake by the T cells. Our results therefore demonstrate that the presence of senescent T cells has a detrimental impact on immune function during type 2 diabetes. John Wiley and Sons Inc. 2019-07-08 2019-08 /pmc/articles/PMC6642873/ /pubmed/31251396 http://dx.doi.org/10.1111/cei.13344 Text en © 2019 The Authors. Clinical & Experimental Immunology published by John Wiley & Sons Ltd on behalf of British Society for Immunology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Lau, E. Y. M. Carroll, E. C. Callender, L. A. Hood, G. A. Berryman, V. Pattrick, M. Finer, S. Hitman, G. A. Ackland, G. L. Henson, S. M. Type 2 diabetes is associated with the accumulation of senescent T cells |
title | Type 2 diabetes is associated with the accumulation of senescent T cells |
title_full | Type 2 diabetes is associated with the accumulation of senescent T cells |
title_fullStr | Type 2 diabetes is associated with the accumulation of senescent T cells |
title_full_unstemmed | Type 2 diabetes is associated with the accumulation of senescent T cells |
title_short | Type 2 diabetes is associated with the accumulation of senescent T cells |
title_sort | type 2 diabetes is associated with the accumulation of senescent t cells |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642873/ https://www.ncbi.nlm.nih.gov/pubmed/31251396 http://dx.doi.org/10.1111/cei.13344 |
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