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Liquid–liquid phase separation of tau protein: The crucial role of electrostatic interactions

Recent studies have indicated that tau, a protein involved in Alzheimer's disease and other neurodegenerative disorders, has a propensity to undergo liquid–liquid phase separation (LLPS). However, the mechanism of this process remains unknown. Here, we demonstrate that tau LLPS is largely drive...

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Detalles Bibliográficos
Autores principales:	Boyko, Solomiia, Qi, Xu, Chen, Tien-Hao, Surewicz, Krystyna, Surewicz, Witold K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Editors' Picks
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643045/ https://www.ncbi.nlm.nih.gov/pubmed/31097543 http://dx.doi.org/10.1074/jbc.AC119.009198

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