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Simvastatin pretreatment ameliorates t-PA–induced hemorrhage transformation and MMP-9/TIMP-1 imbalance in thromboembolic cerebral ischemic rats

Background: The use of thrombolysis with tissue-plasminogen activator (t-PA) in patients with acute ischemic stroke (AIS) is limited by increased levels of matrix metalloproteinase-9 (MMP-9) and by the increased risk of hemorrhagic transformation (HT). In this study, we investigated the effects of s...

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Detalles Bibliográficos
Autores principales:	Yin, Bo, Li, Dan-Dong, Xu, Shang-Yu, Huang, Huan, Lin, Jian, Sheng, Han-Song, Fang, Jun-Hao, Song, Jin-Ning, Zhang, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643059/ https://www.ncbi.nlm.nih.gov/pubmed/31410004 http://dx.doi.org/10.2147/NDT.S199371

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