Cargando…

The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer

Background: The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is hyperactivated in lung cancer and regulates a broad range of cellular processes, including proliferation, survival, angiogenesis, and metastasis. Thus PI3K is considered a promising target for therapy. To date, PI3K inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Chao, Chen, Yin, Li, Hongjian, Yang, Yi, Zhang, Hongtao, Ke, Kunbin, Shi, Xi-Nan, Liu, Xu, Li, Ling, Ma, Jing, Kung, Hsiang-Fu, Chen, Ceshi, Lin, Marie Chia-mi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643147/ https://www.ncbi.nlm.nih.gov/pubmed/31337981 http://dx.doi.org/10.7150/ijbs.32625

Ejemplares similares

Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells
por: Dong, Chao, et al.
Publicado: (2017)

Flupentixol tartrate
por: Yamuna, Thammarse S., et al.
Publicado: (2014)

Association between cumulative exposure periods of flupentixol or any antipsychotics and risk of lung cancer
por: Chai, Yi, et al.
Publicado: (2023)

Melitracen and flupentixol (deanxit) use disorder in Lebanon
por: El Zahran, Tharwat, et al.
Publicado: (2023)

Case report: Extrapontine myelinolysis combined with flupentixol- and melitracen-induced dysphagia
por: Zhao, Zhihong, et al.
Publicado: (2023)

The management challenges of a case with Flupentixol‐induced neuroleptic malignant syndrome
por: Elyasi, Forouzan, et al.
Publicado: (2022)

The Efficacy of Flupentixol-Melitracen in the Adjuvant Therapy of Ulcerative Colitis in the Chinese Population: A Meta-Analysis
por: Zhou, Xiaoqian, et al.
Publicado: (2019)

Estimating the optimal dose of flupentixol decanoate in the maintenance treatment of schizophrenia—a systematic review of the literature
por: Bailey, Loren, et al.
Publicado: (2019)

Acute-onset Orofacial Dyskinesia with a Single Low Dose of Oral Flupentixol: A Case Report
por: Gupta, Prashant, et al.
Publicado: (2018)

Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer
por: Dong, Chao, et al.
Publicado: (2021)

Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma
por: SHI, XI-NAN, et al.
Publicado: (2015)

Efficacy and safety of pinaverium bromide combined with flupentixol-melitracen for diarrhea-type irritable bowel syndrome: A systematic review and meta-analysis
por: Qin, Lifeng, et al.
Publicado: (2019)

Taccalonolides: A Novel Class of Microtubule-Stabilizing Anticancer Agents
por: Chen, Xiaoyan, et al.
Publicado: (2021)

Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data
por: Cheng, H-W, et al.
Publicado: (2015)

Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways
por: García-Echeverría, Carlos
Publicado: (2008)

Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562
por: El-Dydamony, Nehad M., et al.
Publicado: (2022)

Bioequivalence Study Of A Fixed-Dose Combination Tablet Containing Melitracen 10 mg And Flupentixol 0.5 mg In Healthy Chinese Volunteers Under Fasted And Fed Conditions
por: Wu, Lihua, et al.
Publicado: (2019)

Antipsychotic agent pimozide promotes reversible proliferative suppression by inducing cellular quiescence in liver cancer
por: Chen, Jia-Jie, et al.
Publicado: (2019)

In Silico Identification and In Vitro and In Vivo Validation of Anti-Psychotic Drug Fluspirilene as a Potential CDK2 Inhibitor and a Candidate Anti-Cancer Drug
por: Shi, Xi-Nan, et al.
Publicado: (2015)

Newly Synthesized Pyrazolinone Chalcones as Anticancer Agents via Inhibiting the PI3K/Akt/ERK1/2 Signaling Pathway
por: Noser, Ahmed A., et al.
Publicado: (2022)

Antipsychotic agents: efficacy and safety in schizophrenia
por: de Araújo, Arão Nogueira, et al.
Publicado: (2012)

Digoxin exerts anticancer activity on human nonsmall cell lung cancer cells by blocking PI3K/Akt pathway
por: Wang, Yingying, et al.
Publicado: (2021)

Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents–A drug repurposing strategy
por: Wu, Chia-Hsien, et al.
Publicado: (2016)

Ginsenoside Rg3 enhances the anticancer effect of 5-FU in colon cancer cells via the PI3K/AKT pathway
por: Hong, Shunzhong, et al.
Publicado: (2020)

PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors
por: Dituri, Francesco, et al.
Publicado: (2011)

Anticancer activity of THMPP: Downregulation of PI3K/ S6K1 in breast cancer cell line
por: Palanivel, Suresh, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of 6-(Imidazo[1,2-a]pyridin-6-yl)quinazoline Derivatives as Anticancer Agents via PI3Kα Inhibition
por: Li, Mei, et al.
Publicado: (2023)

Selection Study for B+- -> (K-+ pi+- pi-+ pi+-)D K+- and B+- -> (K+ K- pi+ pi-)D K+-".
por: Hunt, P, et al.
Publicado: (2009)

Saponins from Chinese Medicines as Anticancer Agents
por: Xu, Xiao-Huang, et al.
Publicado: (2016)

Pogostemon cablin extract as an anticancer agent on human acute myeloid leukemia
por: Chien, Ju‐Huei, et al.
Publicado: (2021)

The investigation of $K^+\pi^−, \pi^+K^−$ and $\pi^+\pi^−$ atoms
por: Yazkov, Valeriy
Publicado: (2016)

The Antipsychotic Agent Sertindole Exhibited Antiproliferative Activities by Inhibiting the STAT3 Signaling Pathway in Human Gastric Cancer Cells
por: Dai, Chunyan, et al.
Publicado: (2020)

Anticancer Activity of New Na(I) Complex on Retinoblastoma Cells via Inhibiting PI3K/AKT/mTOR Pathway
por: Zhang, Jun, et al.
Publicado: (2021)

Flavonoids as Anticancer Agents
por: Kopustinskiene, Dalia M., et al.
Publicado: (2020)

Discovery of New Glucose Uptake Inhibitors as Potential Anticancer Agents by Non-Radioactive Cell-Based Assays
por: Hung, Hsueh-Chih, et al.
Publicado: (2022)

Anticancer agents : frontiers in cancer chemotherapy /
Publicado: (2001)

Tenacissoside H Induces Autophagy and Radiosensitivity of Hepatocellular Carcinoma Cells by PI3K/Akt/mTOR Signaling Pathway
por: Lin, Jiatian, et al.
Publicado: (2021)

Study of the K+K-pi+pi- system centrally produced in the reactions pi+p --> pi+(K+K-pi+pi-)p and pp --> p(K+K-pi+pi-)p at 85 GeV/c
por: Armstrong, T A, et al.
Publicado: (1986)

TBX2 and TBX3: The special value for anticancer drug targets
por: Lu, Juan, et al.
Publicado: (2010)

Natural Cyclopeptides as Anticancer Agents in the Last 20 Years
por: Zhang, Jia-Nan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_680tg1vm37aad3accrdhkfksl5