An Overlapping Case of IgG4-Related Disease and Systemic Lupus Erythematosus

We are reporting a case of a 63-year-old Chinese female who presented to the rheumatology clinic with positive antinuclear antibody and unintentional weight loss along with lymphadenopathy. Further workup revealed eosinophilia, elevated anti–double stranded DNA, serum protein, and serum IgG4 (immuno...

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Detalles Bibliográficos
Autores principales: Naramala, Srikanth, Biswas, Sharmi, Adapa, Sreedhar, Gayam, Vijay, Konala, Venu Madhav, Bose, Subhasish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643167/
https://www.ncbi.nlm.nih.gov/pubmed/31319713
http://dx.doi.org/10.1177/2324709619862297
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author Naramala, Srikanth
Biswas, Sharmi
Adapa, Sreedhar
Gayam, Vijay
Konala, Venu Madhav
Bose, Subhasish
author_facet Naramala, Srikanth
Biswas, Sharmi
Adapa, Sreedhar
Gayam, Vijay
Konala, Venu Madhav
Bose, Subhasish
author_sort Naramala, Srikanth
collection PubMed
description We are reporting a case of a 63-year-old Chinese female who presented to the rheumatology clinic with positive antinuclear antibody and unintentional weight loss along with lymphadenopathy. Further workup revealed eosinophilia, elevated anti–double stranded DNA, serum protein, and serum IgG4 (immunoglobulin G4). The patient was diagnosed with systemic lupus erythematosus. Due to the raised IgG4 level along with eosinophilia and diffuse lymphadenopathy, IgG4-related systemic disease was suspected. It was confirmed with IgG4 staining on lymph node biopsy. Our case is presenting the fact that systemic lupus erythematosus and IgG4-related disease can be present in the same patient with multiple overlapping features making accurate diagnosis challenging.
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spelling pubmed-66431672019-07-31 An Overlapping Case of IgG4-Related Disease and Systemic Lupus Erythematosus Naramala, Srikanth Biswas, Sharmi Adapa, Sreedhar Gayam, Vijay Konala, Venu Madhav Bose, Subhasish J Investig Med High Impact Case Rep Case Report We are reporting a case of a 63-year-old Chinese female who presented to the rheumatology clinic with positive antinuclear antibody and unintentional weight loss along with lymphadenopathy. Further workup revealed eosinophilia, elevated anti–double stranded DNA, serum protein, and serum IgG4 (immunoglobulin G4). The patient was diagnosed with systemic lupus erythematosus. Due to the raised IgG4 level along with eosinophilia and diffuse lymphadenopathy, IgG4-related systemic disease was suspected. It was confirmed with IgG4 staining on lymph node biopsy. Our case is presenting the fact that systemic lupus erythematosus and IgG4-related disease can be present in the same patient with multiple overlapping features making accurate diagnosis challenging. SAGE Publications 2019-07-18 /pmc/articles/PMC6643167/ /pubmed/31319713 http://dx.doi.org/10.1177/2324709619862297 Text en © 2019 American Federation for Medical Research http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Naramala, Srikanth
Biswas, Sharmi
Adapa, Sreedhar
Gayam, Vijay
Konala, Venu Madhav
Bose, Subhasish
An Overlapping Case of IgG4-Related Disease and Systemic Lupus Erythematosus
title An Overlapping Case of IgG4-Related Disease and Systemic Lupus Erythematosus
title_full An Overlapping Case of IgG4-Related Disease and Systemic Lupus Erythematosus
title_fullStr An Overlapping Case of IgG4-Related Disease and Systemic Lupus Erythematosus
title_full_unstemmed An Overlapping Case of IgG4-Related Disease and Systemic Lupus Erythematosus
title_short An Overlapping Case of IgG4-Related Disease and Systemic Lupus Erythematosus
title_sort overlapping case of igg4-related disease and systemic lupus erythematosus
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643167/
https://www.ncbi.nlm.nih.gov/pubmed/31319713
http://dx.doi.org/10.1177/2324709619862297
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