XX sex chromosome complement promotes atherosclerosis in mice

Men and women differ in circulating lipids and coronary artery disease (CAD). While sex hormones such as estrogens decrease CAD risk, hormone replacement therapy increases risk. Biological sex is determined by sex hormones and chromosomes, but effects of sex chromosomes on circulating lipids and ath...

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Autores principales: AlSiraj, Yasir, Chen, Xuqi, Thatcher, Sean E., Temel, Ryan E., Cai, Lei, Blalock, Eric, Katz, Wendy, Ali, Heba M., Petriello, Michael, Deng, Pan, Morris, Andrew J., Wang, Xuping, Lusis, Aldons J., Arnold, Arthur P., Reue, Karen, Thompson, Katherine, Tso, Patrick, Cassis, Lisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643208/
https://www.ncbi.nlm.nih.gov/pubmed/31201301
http://dx.doi.org/10.1038/s41467-019-10462-z
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author AlSiraj, Yasir
Chen, Xuqi
Thatcher, Sean E.
Temel, Ryan E.
Cai, Lei
Blalock, Eric
Katz, Wendy
Ali, Heba M.
Petriello, Michael
Deng, Pan
Morris, Andrew J.
Wang, Xuping
Lusis, Aldons J.
Arnold, Arthur P.
Reue, Karen
Thompson, Katherine
Tso, Patrick
Cassis, Lisa A.
author_facet AlSiraj, Yasir
Chen, Xuqi
Thatcher, Sean E.
Temel, Ryan E.
Cai, Lei
Blalock, Eric
Katz, Wendy
Ali, Heba M.
Petriello, Michael
Deng, Pan
Morris, Andrew J.
Wang, Xuping
Lusis, Aldons J.
Arnold, Arthur P.
Reue, Karen
Thompson, Katherine
Tso, Patrick
Cassis, Lisa A.
author_sort AlSiraj, Yasir
collection PubMed
description Men and women differ in circulating lipids and coronary artery disease (CAD). While sex hormones such as estrogens decrease CAD risk, hormone replacement therapy increases risk. Biological sex is determined by sex hormones and chromosomes, but effects of sex chromosomes on circulating lipids and atherosclerosis are unknown. Here, we use mouse models to separate effects of sex chromosomes and hormones on atherosclerosis, circulating lipids and intestinal fat metabolism. We assess atherosclerosis in multiple models and experimental paradigms that distinguish effects of sex chromosomes, and male or female gonads. Pro-atherogenic lipids and atherosclerosis are greater in XX than XY mice, indicating a primary effect of sex chromosomes. Small intestine expression of enzymes involved in lipid absorption and chylomicron assembly are greater in XX male and female mice with higher intestinal lipids. Together, our results show that an XX sex chromosome complement promotes the bioavailability of dietary fat to accelerate atherosclerosis.
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spelling pubmed-66432082019-07-23 XX sex chromosome complement promotes atherosclerosis in mice AlSiraj, Yasir Chen, Xuqi Thatcher, Sean E. Temel, Ryan E. Cai, Lei Blalock, Eric Katz, Wendy Ali, Heba M. Petriello, Michael Deng, Pan Morris, Andrew J. Wang, Xuping Lusis, Aldons J. Arnold, Arthur P. Reue, Karen Thompson, Katherine Tso, Patrick Cassis, Lisa A. Nat Commun Article Men and women differ in circulating lipids and coronary artery disease (CAD). While sex hormones such as estrogens decrease CAD risk, hormone replacement therapy increases risk. Biological sex is determined by sex hormones and chromosomes, but effects of sex chromosomes on circulating lipids and atherosclerosis are unknown. Here, we use mouse models to separate effects of sex chromosomes and hormones on atherosclerosis, circulating lipids and intestinal fat metabolism. We assess atherosclerosis in multiple models and experimental paradigms that distinguish effects of sex chromosomes, and male or female gonads. Pro-atherogenic lipids and atherosclerosis are greater in XX than XY mice, indicating a primary effect of sex chromosomes. Small intestine expression of enzymes involved in lipid absorption and chylomicron assembly are greater in XX male and female mice with higher intestinal lipids. Together, our results show that an XX sex chromosome complement promotes the bioavailability of dietary fat to accelerate atherosclerosis. Nature Publishing Group UK 2019-06-14 /pmc/articles/PMC6643208/ /pubmed/31201301 http://dx.doi.org/10.1038/s41467-019-10462-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
AlSiraj, Yasir
Chen, Xuqi
Thatcher, Sean E.
Temel, Ryan E.
Cai, Lei
Blalock, Eric
Katz, Wendy
Ali, Heba M.
Petriello, Michael
Deng, Pan
Morris, Andrew J.
Wang, Xuping
Lusis, Aldons J.
Arnold, Arthur P.
Reue, Karen
Thompson, Katherine
Tso, Patrick
Cassis, Lisa A.
XX sex chromosome complement promotes atherosclerosis in mice
title XX sex chromosome complement promotes atherosclerosis in mice
title_full XX sex chromosome complement promotes atherosclerosis in mice
title_fullStr XX sex chromosome complement promotes atherosclerosis in mice
title_full_unstemmed XX sex chromosome complement promotes atherosclerosis in mice
title_short XX sex chromosome complement promotes atherosclerosis in mice
title_sort xx sex chromosome complement promotes atherosclerosis in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643208/
https://www.ncbi.nlm.nih.gov/pubmed/31201301
http://dx.doi.org/10.1038/s41467-019-10462-z
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