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Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2

Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women in the worldwide. Triple-negative breast cancer (TNBC) has a poor clinical outcome. The antitumor efficacy of Ilamycins, natural products with anti-tuberculosis activity isolated from deep sea-deriv...

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Autores principales: Zhou, Wenhui, Fang, Huan, Wu, Qiuju, Wang, Xinye, Liu, Rong, Li, Fubin, Xiao, Ji, Yuan, Lin, Zhou, Zhongmei, Ma, Junying, Wang, Lulu, Zhao, Weiwei, You, Hua, Ju, Jianhua, Feng, Jing, Chen, Ceshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643221/
https://www.ncbi.nlm.nih.gov/pubmed/31360114
http://dx.doi.org/10.7150/ijbs.35284
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author Zhou, Wenhui
Fang, Huan
Wu, Qiuju
Wang, Xinye
Liu, Rong
Li, Fubin
Xiao, Ji
Yuan, Lin
Zhou, Zhongmei
Ma, Junying
Wang, Lulu
Zhao, Weiwei
You, Hua
Ju, Jianhua
Feng, Jing
Chen, Ceshi
author_facet Zhou, Wenhui
Fang, Huan
Wu, Qiuju
Wang, Xinye
Liu, Rong
Li, Fubin
Xiao, Ji
Yuan, Lin
Zhou, Zhongmei
Ma, Junying
Wang, Lulu
Zhao, Weiwei
You, Hua
Ju, Jianhua
Feng, Jing
Chen, Ceshi
author_sort Zhou, Wenhui
collection PubMed
description Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women in the worldwide. Triple-negative breast cancer (TNBC) has a poor clinical outcome. The antitumor efficacy of Ilamycins, natural products with anti-tuberculosis activity isolated from deep sea-derived Streptomyces atratus, in TNBC has not been investigated, and the mechanisms remain elusive. Here, we demonstrated that Ilamycin-E, but not -F, decreases cell viability, inhibits G1/S cell cycle progression, and promotes apoptosis in the TNBC cell lines HCC1937 and MDA-MB-468. Ilamycin E promotes apoptosis via activation of endoplasmic reticulum (ER) stress, increasing the expression of CHOP, and down-regulating the expression of anti-apoptotic protein Bcl-2. Depletion of CHOP or overexpression of Bcl2 significantly rescued Ilamycin E-induced apoptosis. These findings indicate that Ilamycin E has anti-cancer activity in TNBC.
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spelling pubmed-66432212019-07-29 Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2 Zhou, Wenhui Fang, Huan Wu, Qiuju Wang, Xinye Liu, Rong Li, Fubin Xiao, Ji Yuan, Lin Zhou, Zhongmei Ma, Junying Wang, Lulu Zhao, Weiwei You, Hua Ju, Jianhua Feng, Jing Chen, Ceshi Int J Biol Sci Research Paper Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women in the worldwide. Triple-negative breast cancer (TNBC) has a poor clinical outcome. The antitumor efficacy of Ilamycins, natural products with anti-tuberculosis activity isolated from deep sea-derived Streptomyces atratus, in TNBC has not been investigated, and the mechanisms remain elusive. Here, we demonstrated that Ilamycin-E, but not -F, decreases cell viability, inhibits G1/S cell cycle progression, and promotes apoptosis in the TNBC cell lines HCC1937 and MDA-MB-468. Ilamycin E promotes apoptosis via activation of endoplasmic reticulum (ER) stress, increasing the expression of CHOP, and down-regulating the expression of anti-apoptotic protein Bcl-2. Depletion of CHOP or overexpression of Bcl2 significantly rescued Ilamycin E-induced apoptosis. These findings indicate that Ilamycin E has anti-cancer activity in TNBC. Ivyspring International Publisher 2019-06-10 /pmc/articles/PMC6643221/ /pubmed/31360114 http://dx.doi.org/10.7150/ijbs.35284 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Zhou, Wenhui
Fang, Huan
Wu, Qiuju
Wang, Xinye
Liu, Rong
Li, Fubin
Xiao, Ji
Yuan, Lin
Zhou, Zhongmei
Ma, Junying
Wang, Lulu
Zhao, Weiwei
You, Hua
Ju, Jianhua
Feng, Jing
Chen, Ceshi
Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2
title Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2
title_full Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2
title_fullStr Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2
title_full_unstemmed Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2
title_short Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2
title_sort ilamycin e, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through er stress-chop-bcl-2
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643221/
https://www.ncbi.nlm.nih.gov/pubmed/31360114
http://dx.doi.org/10.7150/ijbs.35284
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