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The regenerative potential of skin and the immune system

Skin has the natural ability to heal and replace dead cells regulated by a network of complex immune processes. This ability is conferred by the population of resident immune cells that act in coordination with other players to provide a homeostatic environment under constant challenge. Other than p...

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Autores principales: Tsepkolenko, Anna, Tsepkolenko, Vladimir, Dash, Sabyasachi, Mishra, Apoorva, Bader, Augustinus, Melerzanov, Alexander, Giri, Shibashish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643261/
https://www.ncbi.nlm.nih.gov/pubmed/31410045
http://dx.doi.org/10.2147/CCID.S196364
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author Tsepkolenko, Anna
Tsepkolenko, Vladimir
Dash, Sabyasachi
Mishra, Apoorva
Bader, Augustinus
Melerzanov, Alexander
Giri, Shibashish
author_facet Tsepkolenko, Anna
Tsepkolenko, Vladimir
Dash, Sabyasachi
Mishra, Apoorva
Bader, Augustinus
Melerzanov, Alexander
Giri, Shibashish
author_sort Tsepkolenko, Anna
collection PubMed
description Skin has the natural ability to heal and replace dead cells regulated by a network of complex immune processes. This ability is conferred by the population of resident immune cells that act in coordination with other players to provide a homeostatic environment under constant challenge. Other than providing structure and integrity, the epidermis and dermis also house distinct immune properties. The dermal part is represented by fibroblasts and endothelial cells followed by an array of immune cells which includes dendritic cells (DCs), macrophages, mast cells, NK-cells, neutrophils, basophils, eosinophils, αβ T lymphocytes, B-cells and platelets. On the other hand, the functionally active immune cells in the epidermis comprise keratinocytes, DCs, NKT-cells, γδ T cells and αβ T cells (CD4+ and CD8+). Keratinocytes create a unique microenvironment for the cells of the immune system by promoting immune recognition and cellular differentiation. T lymphocytes exhibit tissue-specific tropism toward the epidermis and the lymphatic drainage system important for their function in immune regulation. This diversity in immune regulators makes the skin a unique organ to overcome pathogenic or foreign invasion. In addition, the highly coordinated molecular events make the skin an attractive model to understand and explore its regenerative potential.
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spelling pubmed-66432612019-08-13 The regenerative potential of skin and the immune system Tsepkolenko, Anna Tsepkolenko, Vladimir Dash, Sabyasachi Mishra, Apoorva Bader, Augustinus Melerzanov, Alexander Giri, Shibashish Clin Cosmet Investig Dermatol Review Skin has the natural ability to heal and replace dead cells regulated by a network of complex immune processes. This ability is conferred by the population of resident immune cells that act in coordination with other players to provide a homeostatic environment under constant challenge. Other than providing structure and integrity, the epidermis and dermis also house distinct immune properties. The dermal part is represented by fibroblasts and endothelial cells followed by an array of immune cells which includes dendritic cells (DCs), macrophages, mast cells, NK-cells, neutrophils, basophils, eosinophils, αβ T lymphocytes, B-cells and platelets. On the other hand, the functionally active immune cells in the epidermis comprise keratinocytes, DCs, NKT-cells, γδ T cells and αβ T cells (CD4+ and CD8+). Keratinocytes create a unique microenvironment for the cells of the immune system by promoting immune recognition and cellular differentiation. T lymphocytes exhibit tissue-specific tropism toward the epidermis and the lymphatic drainage system important for their function in immune regulation. This diversity in immune regulators makes the skin a unique organ to overcome pathogenic or foreign invasion. In addition, the highly coordinated molecular events make the skin an attractive model to understand and explore its regenerative potential. Dove 2019-07-15 /pmc/articles/PMC6643261/ /pubmed/31410045 http://dx.doi.org/10.2147/CCID.S196364 Text en © 2019 Tsepkolenko et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Tsepkolenko, Anna
Tsepkolenko, Vladimir
Dash, Sabyasachi
Mishra, Apoorva
Bader, Augustinus
Melerzanov, Alexander
Giri, Shibashish
The regenerative potential of skin and the immune system
title The regenerative potential of skin and the immune system
title_full The regenerative potential of skin and the immune system
title_fullStr The regenerative potential of skin and the immune system
title_full_unstemmed The regenerative potential of skin and the immune system
title_short The regenerative potential of skin and the immune system
title_sort regenerative potential of skin and the immune system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643261/
https://www.ncbi.nlm.nih.gov/pubmed/31410045
http://dx.doi.org/10.2147/CCID.S196364
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