The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response

Cyclophilin A (CypA) is a multifunctional protein that exhibits an isomerase activity and exists in the intracellular and secretory forms. Secretory CypA promotes regeneration of the hematopoietic and the immune systems of an organism by stimulating stem cell migration from the bone marrow. New appr...

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Detalles Bibliográficos
Autores principales: Kalinina, A. A., Silaeva, Yu. Yu., Kazansky, D. B., Khromykh, L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643350/
https://www.ncbi.nlm.nih.gov/pubmed/31413881
http://dx.doi.org/10.32607/20758251-2019-11-2-63-67
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author Kalinina, A. A.
Silaeva, Yu. Yu.
Kazansky, D. B.
Khromykh, L. M.
author_facet Kalinina, A. A.
Silaeva, Yu. Yu.
Kazansky, D. B.
Khromykh, L. M.
author_sort Kalinina, A. A.
collection PubMed
description Cyclophilin A (CypA) is a multifunctional protein that exhibits an isomerase activity and exists in the intracellular and secretory forms. Secretory CypA promotes regeneration of the hematopoietic and the immune systems of an organism by stimulating stem cell migration from the bone marrow. New approaches based on CypA are currently being developed for the treatment of limb ischemia, neutralization of the side effects of Cyclosporine A (CsA) therapy, etc. However, the role of CypA in the antitumor immune response is still unexplored. In this work, we used the model experimental system of lymphoma EL-4 rejection in B10.D2(R101) mice and showed that recombinant human CypA (rhCypA) stimulates the antitumor immune response via early recruitment of granulocytes to the tumor cell localization site and rapid accumulation of effector T-killers
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spelling pubmed-66433502019-08-14 The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response Kalinina, A. A. Silaeva, Yu. Yu. Kazansky, D. B. Khromykh, L. M. Acta Naturae Research Article Cyclophilin A (CypA) is a multifunctional protein that exhibits an isomerase activity and exists in the intracellular and secretory forms. Secretory CypA promotes regeneration of the hematopoietic and the immune systems of an organism by stimulating stem cell migration from the bone marrow. New approaches based on CypA are currently being developed for the treatment of limb ischemia, neutralization of the side effects of Cyclosporine A (CsA) therapy, etc. However, the role of CypA in the antitumor immune response is still unexplored. In this work, we used the model experimental system of lymphoma EL-4 rejection in B10.D2(R101) mice and showed that recombinant human CypA (rhCypA) stimulates the antitumor immune response via early recruitment of granulocytes to the tumor cell localization site and rapid accumulation of effector T-killers A.I. Gordeyev 2019 /pmc/articles/PMC6643350/ /pubmed/31413881 http://dx.doi.org/10.32607/20758251-2019-11-2-63-67 Text en Copyright ® 2019 National Research University Higher School of Economics. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kalinina, A. A.
Silaeva, Yu. Yu.
Kazansky, D. B.
Khromykh, L. M.
The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response
title The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response
title_full The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response
title_fullStr The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response
title_full_unstemmed The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response
title_short The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response
title_sort role of recombinant human cyclophilin a in the antitumor immune response
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643350/
https://www.ncbi.nlm.nih.gov/pubmed/31413881
http://dx.doi.org/10.32607/20758251-2019-11-2-63-67
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