Metal-Free Synthesis of Functionalized Tetrasubstituted Alkenes by Three-Component Reaction of Alkynes, Iodine, and Sodium Sulfinates

[Image: see text] An operationally simple, efficient, and metal-/peroxide-free three-component reaction of alkynes, iodine, and sodium sulfinates has been developed for the construction of highly functionalized tetrasubstituted alkenes. Iodo- and sulfonyl-containing tetrasubstituted alkenes, such as...

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Autores principales: Zhang, Jitan, Liang, Zhenda, Wang, Jun, Guo, Ziyi, Liu, Changqing, Xie, Meihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643681/
https://www.ncbi.nlm.nih.gov/pubmed/31458390
http://dx.doi.org/10.1021/acsomega.8b02966
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author Zhang, Jitan
Liang, Zhenda
Wang, Jun
Guo, Ziyi
Liu, Changqing
Xie, Meihua
author_facet Zhang, Jitan
Liang, Zhenda
Wang, Jun
Guo, Ziyi
Liu, Changqing
Xie, Meihua
author_sort Zhang, Jitan
collection PubMed
description [Image: see text] An operationally simple, efficient, and metal-/peroxide-free three-component reaction of alkynes, iodine, and sodium sulfinates has been developed for the construction of highly functionalized tetrasubstituted alkenes. Iodo- and sulfonyl-containing tetrasubstituted alkenes, such as vinyl ketones, allylic alcohols, and conjugated enynes, could be obtained regio- and stereoselectively in up to 96% yield.
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spelling pubmed-66436812019-08-27 Metal-Free Synthesis of Functionalized Tetrasubstituted Alkenes by Three-Component Reaction of Alkynes, Iodine, and Sodium Sulfinates Zhang, Jitan Liang, Zhenda Wang, Jun Guo, Ziyi Liu, Changqing Xie, Meihua ACS Omega [Image: see text] An operationally simple, efficient, and metal-/peroxide-free three-component reaction of alkynes, iodine, and sodium sulfinates has been developed for the construction of highly functionalized tetrasubstituted alkenes. Iodo- and sulfonyl-containing tetrasubstituted alkenes, such as vinyl ketones, allylic alcohols, and conjugated enynes, could be obtained regio- and stereoselectively in up to 96% yield. American Chemical Society 2018-12-21 /pmc/articles/PMC6643681/ /pubmed/31458390 http://dx.doi.org/10.1021/acsomega.8b02966 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Zhang, Jitan
Liang, Zhenda
Wang, Jun
Guo, Ziyi
Liu, Changqing
Xie, Meihua
Metal-Free Synthesis of Functionalized Tetrasubstituted Alkenes by Three-Component Reaction of Alkynes, Iodine, and Sodium Sulfinates
title Metal-Free Synthesis of Functionalized Tetrasubstituted Alkenes by Three-Component Reaction of Alkynes, Iodine, and Sodium Sulfinates
title_full Metal-Free Synthesis of Functionalized Tetrasubstituted Alkenes by Three-Component Reaction of Alkynes, Iodine, and Sodium Sulfinates
title_fullStr Metal-Free Synthesis of Functionalized Tetrasubstituted Alkenes by Three-Component Reaction of Alkynes, Iodine, and Sodium Sulfinates
title_full_unstemmed Metal-Free Synthesis of Functionalized Tetrasubstituted Alkenes by Three-Component Reaction of Alkynes, Iodine, and Sodium Sulfinates
title_short Metal-Free Synthesis of Functionalized Tetrasubstituted Alkenes by Three-Component Reaction of Alkynes, Iodine, and Sodium Sulfinates
title_sort metal-free synthesis of functionalized tetrasubstituted alkenes by three-component reaction of alkynes, iodine, and sodium sulfinates
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643681/
https://www.ncbi.nlm.nih.gov/pubmed/31458390
http://dx.doi.org/10.1021/acsomega.8b02966
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