Synthetic Access to Cyclopenta[a]inden-2(1H)-ones from Morita–Baylis–Hillman Products of 2-Alkynyl Benzaldehydes

[Image: see text] A new strategy for the synthesis of cyclopenta[a]inden-2(1H)-ones has been developed. An intramolecular Pauson–Khand reaction of the Morita–Baylis–Hillman (MBH) adducts, derived from 2-alkynyl benzaldehydes, provided the consequent novel cyclopenta[a]inden-2(1H)-ones bearing multif...

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Autores principales: Raji Reddy, Chada, Warudikar, Kamalkishor, Sridhar, Balasubramanian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644149/
https://www.ncbi.nlm.nih.gov/pubmed/31458226
http://dx.doi.org/10.1021/acsomega.8b02111
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author Raji Reddy, Chada
Warudikar, Kamalkishor
Sridhar, Balasubramanian
author_facet Raji Reddy, Chada
Warudikar, Kamalkishor
Sridhar, Balasubramanian
author_sort Raji Reddy, Chada
collection PubMed
description [Image: see text] A new strategy for the synthesis of cyclopenta[a]inden-2(1H)-ones has been developed. An intramolecular Pauson–Khand reaction of the Morita–Baylis–Hillman (MBH) adducts, derived from 2-alkynyl benzaldehydes, provided the consequent novel cyclopenta[a]inden-2(1H)-ones bearing multifunctionalities including an ester group at the fused ring junction (tert-carbon center). The generality of this approach was illustrated by studying the several MBH derivatives containing diverse substitutions/functionalities.
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spelling pubmed-66441492019-08-27 Synthetic Access to Cyclopenta[a]inden-2(1H)-ones from Morita–Baylis–Hillman Products of 2-Alkynyl Benzaldehydes Raji Reddy, Chada Warudikar, Kamalkishor Sridhar, Balasubramanian ACS Omega [Image: see text] A new strategy for the synthesis of cyclopenta[a]inden-2(1H)-ones has been developed. An intramolecular Pauson–Khand reaction of the Morita–Baylis–Hillman (MBH) adducts, derived from 2-alkynyl benzaldehydes, provided the consequent novel cyclopenta[a]inden-2(1H)-ones bearing multifunctionalities including an ester group at the fused ring junction (tert-carbon center). The generality of this approach was illustrated by studying the several MBH derivatives containing diverse substitutions/functionalities. American Chemical Society 2018-11-19 /pmc/articles/PMC6644149/ /pubmed/31458226 http://dx.doi.org/10.1021/acsomega.8b02111 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Raji Reddy, Chada
Warudikar, Kamalkishor
Sridhar, Balasubramanian
Synthetic Access to Cyclopenta[a]inden-2(1H)-ones from Morita–Baylis–Hillman Products of 2-Alkynyl Benzaldehydes
title Synthetic Access to Cyclopenta[a]inden-2(1H)-ones from Morita–Baylis–Hillman Products of 2-Alkynyl Benzaldehydes
title_full Synthetic Access to Cyclopenta[a]inden-2(1H)-ones from Morita–Baylis–Hillman Products of 2-Alkynyl Benzaldehydes
title_fullStr Synthetic Access to Cyclopenta[a]inden-2(1H)-ones from Morita–Baylis–Hillman Products of 2-Alkynyl Benzaldehydes
title_full_unstemmed Synthetic Access to Cyclopenta[a]inden-2(1H)-ones from Morita–Baylis–Hillman Products of 2-Alkynyl Benzaldehydes
title_short Synthetic Access to Cyclopenta[a]inden-2(1H)-ones from Morita–Baylis–Hillman Products of 2-Alkynyl Benzaldehydes
title_sort synthetic access to cyclopenta[a]inden-2(1h)-ones from morita–baylis–hillman products of 2-alkynyl benzaldehydes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644149/
https://www.ncbi.nlm.nih.gov/pubmed/31458226
http://dx.doi.org/10.1021/acsomega.8b02111
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