Synthesis of 3-Hydroxy-4-Substituted Picolinonitriles from 4-Propargylaminoisoxazoles via Stepwise and One-Pot Isoxazolopyridine Formation/N–O Bond Cleavage Sequence

[Image: see text] A unique synthetic approach to 3-hydroxy-4-substituted picolinonitriles is achieved via gold(I)-catalyzed cyclization of 4-propargylaminoisoxazoles and subsequent N–O bond cleavage of isoxazolopyridines under mild reaction conditions in a stepwise and one-pot fashion.

Detalles Bibliográficos
Autores principales: Fukuhara, Shintaro, Yugandar, Somaraju, Fuse, Shinichiro, Nakamura, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644211/
https://www.ncbi.nlm.nih.gov/pubmed/31458282
http://dx.doi.org/10.1021/acsomega.8b03114
Descripción
Sumario:[Image: see text] A unique synthetic approach to 3-hydroxy-4-substituted picolinonitriles is achieved via gold(I)-catalyzed cyclization of 4-propargylaminoisoxazoles and subsequent N–O bond cleavage of isoxazolopyridines under mild reaction conditions in a stepwise and one-pot fashion.

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