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1,3-Dibromo-1,1-difluoro-2-propanone as a Useful Synthon for a Chemoselective Preparation of 4-Bromodifluoromethyl Thiazoles

[Image: see text] We report herein a synthetic protocol for the preparation of 1,3-dibromo-1,1-difluoro-2-propanone, a new synthon used for the first time in a reaction with aromatic amines and sodium thiocyanate, leading to thiazoles which are useful candidates in drug discovery programs. The new s...

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Detalles Bibliográficos
Autores principales:	Colella, Marco, Musci, Pantaleo, Carlucci, Claudia, Lillini, Samuele, Tomassetti, Mara, Aramini, Andrea, Degennaro, Leonardo, Luisi, Renzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644220/ https://www.ncbi.nlm.nih.gov/pubmed/31458153 http://dx.doi.org/10.1021/acsomega.8b02273

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