Negative Cooperative Binding of Thymidine, Ordered Substrate Binding, and Product Release of Human Mitochondrial Thymidine Kinase 2 Explain Its Complex Kinetic Properties and Physiological Functions

[Image: see text] Mitochondrial thymidine kinase 2 (TK2) catalyzes the phosphorylation of thymidine (dT) and deoxycytidine (dC) and is essential for mitochondrial function in post-mitotic tissues. The phosphorylation of dT shows negative cooperativity, but the phosphorylation of dC follows classical...

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Detalles Bibliográficos
Autores principales: Wang, Liya, Zhang, Li, Sun, Ren, Eriksson, Staffan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644362/
https://www.ncbi.nlm.nih.gov/pubmed/31459030
http://dx.doi.org/10.1021/acsomega.8b01376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644362/
https://www.ncbi.nlm.nih.gov/pubmed/31459030
http://dx.doi.org/10.1021/acsomega.8b01376

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