Extent of Helical Induction Caused by Introducing α-Aminoisobutyric Acid into an Oligovaline Sequence

[Image: see text] The preferred conformations of a dodecapeptide composed of l-valine (l-Val) and α-aminoisobutyric acid (Aib) residues, Boc-(l-Val-l-Val-Aib)(4)-OMe (3), were analyzed in solution and in the crystalline state. Peptide 3 predominantly folded into a mixture of α- and 3(10)-(P) helical...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsuji, Genichiro, Misawa, Takashi, Doi, Mitsunobu, Demizu, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644412/
https://www.ncbi.nlm.nih.gov/pubmed/31458822
http://dx.doi.org/10.1021/acsomega.8b01030
_version_ 1783437248405962752
author Tsuji, Genichiro
Misawa, Takashi
Doi, Mitsunobu
Demizu, Yosuke
author_facet Tsuji, Genichiro
Misawa, Takashi
Doi, Mitsunobu
Demizu, Yosuke
author_sort Tsuji, Genichiro
collection PubMed
description [Image: see text] The preferred conformations of a dodecapeptide composed of l-valine (l-Val) and α-aminoisobutyric acid (Aib) residues, Boc-(l-Val-l-Val-Aib)(4)-OMe (3), were analyzed in solution and in the crystalline state. Peptide 3 predominantly folded into a mixture of α- and 3(10)-(P) helical structures in solution and a (P) α helix in the crystalline state.
format Online
Article
Text
id pubmed-6644412
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-66444122019-08-27 Extent of Helical Induction Caused by Introducing α-Aminoisobutyric Acid into an Oligovaline Sequence Tsuji, Genichiro Misawa, Takashi Doi, Mitsunobu Demizu, Yosuke ACS Omega [Image: see text] The preferred conformations of a dodecapeptide composed of l-valine (l-Val) and α-aminoisobutyric acid (Aib) residues, Boc-(l-Val-l-Val-Aib)(4)-OMe (3), were analyzed in solution and in the crystalline state. Peptide 3 predominantly folded into a mixture of α- and 3(10)-(P) helical structures in solution and a (P) α helix in the crystalline state. American Chemical Society 2018-06-14 /pmc/articles/PMC6644412/ /pubmed/31458822 http://dx.doi.org/10.1021/acsomega.8b01030 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Tsuji, Genichiro
Misawa, Takashi
Doi, Mitsunobu
Demizu, Yosuke
Extent of Helical Induction Caused by Introducing α-Aminoisobutyric Acid into an Oligovaline Sequence
title Extent of Helical Induction Caused by Introducing α-Aminoisobutyric Acid into an Oligovaline Sequence
title_full Extent of Helical Induction Caused by Introducing α-Aminoisobutyric Acid into an Oligovaline Sequence
title_fullStr Extent of Helical Induction Caused by Introducing α-Aminoisobutyric Acid into an Oligovaline Sequence
title_full_unstemmed Extent of Helical Induction Caused by Introducing α-Aminoisobutyric Acid into an Oligovaline Sequence
title_short Extent of Helical Induction Caused by Introducing α-Aminoisobutyric Acid into an Oligovaline Sequence
title_sort extent of helical induction caused by introducing α-aminoisobutyric acid into an oligovaline sequence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644412/
https://www.ncbi.nlm.nih.gov/pubmed/31458822
http://dx.doi.org/10.1021/acsomega.8b01030
work_keys_str_mv AT tsujigenichiro extentofhelicalinductioncausedbyintroducingaaminoisobutyricacidintoanoligovalinesequence
AT misawatakashi extentofhelicalinductioncausedbyintroducingaaminoisobutyricacidintoanoligovalinesequence
AT doimitsunobu extentofhelicalinductioncausedbyintroducingaaminoisobutyricacidintoanoligovalinesequence
AT demizuyosuke extentofhelicalinductioncausedbyintroducingaaminoisobutyricacidintoanoligovalinesequence

Ejemplares similares