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Causes of Death and Conditional Survival of Renal Cell Carcinoma
Background: As conditional survival could provide more relevant prognostic information at each follow-up time, the present study aimed to assess conditional overall survival (COS) based on two cohorts and assess the risks of death due to renal cell carcinoma (RCC) vs. other causes. Methods: The Fuda...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644417/ https://www.ncbi.nlm.nih.gov/pubmed/31380266 http://dx.doi.org/10.3389/fonc.2019.00591 |
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author | Shao, Ning Wan, Fangning Abudurexiti, Mierxiati Wang, Jun Zhu, Yao Ye, Dingwei |
author_facet | Shao, Ning Wan, Fangning Abudurexiti, Mierxiati Wang, Jun Zhu, Yao Ye, Dingwei |
author_sort | Shao, Ning |
collection | PubMed |
description | Background: As conditional survival could provide more relevant prognostic information at each follow-up time, the present study aimed to assess conditional overall survival (COS) based on two cohorts and assess the risks of death due to renal cell carcinoma (RCC) vs. other causes. Methods: The Fudan University Shanghai Cancer Center (FUSCC) and Surveillance, Epidemiology, and End Results (SEER) database were used as the source of data for our analysis. COS and cancer-specific survival were evaluated using the Kaplan–Meier method. Results: A total of 90,927 patients (SEER cohort = 88,807, FUSCC cohort = 2,120) were enrolled. Our results suggest that hazards of other causes-related death were always higher than that of cancer-specific death in low-risk RCC patients, but lower in metastatic RCC patients. It exceeded that of cancer-specific death by 8 years in high-risk RCC patients. Only in metastatic RCC patients, the COS improved markedly with survivorship increasing. After surviving 1, 2, 3, 4, and 5 years, the 5 years COS increased by +10, +18, +23, +29, and 35% (the observed 5 years OS: 12%), respectively. Conclusions: COS can better help patients with metastatic RCC rather than other RCC patients. Additionally, COS brings optimism for metastatic RCC patients with expected poorer prognosis psychologically. |
format | Online Article Text |
id | pubmed-6644417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66444172019-08-02 Causes of Death and Conditional Survival of Renal Cell Carcinoma Shao, Ning Wan, Fangning Abudurexiti, Mierxiati Wang, Jun Zhu, Yao Ye, Dingwei Front Oncol Oncology Background: As conditional survival could provide more relevant prognostic information at each follow-up time, the present study aimed to assess conditional overall survival (COS) based on two cohorts and assess the risks of death due to renal cell carcinoma (RCC) vs. other causes. Methods: The Fudan University Shanghai Cancer Center (FUSCC) and Surveillance, Epidemiology, and End Results (SEER) database were used as the source of data for our analysis. COS and cancer-specific survival were evaluated using the Kaplan–Meier method. Results: A total of 90,927 patients (SEER cohort = 88,807, FUSCC cohort = 2,120) were enrolled. Our results suggest that hazards of other causes-related death were always higher than that of cancer-specific death in low-risk RCC patients, but lower in metastatic RCC patients. It exceeded that of cancer-specific death by 8 years in high-risk RCC patients. Only in metastatic RCC patients, the COS improved markedly with survivorship increasing. After surviving 1, 2, 3, 4, and 5 years, the 5 years COS increased by +10, +18, +23, +29, and 35% (the observed 5 years OS: 12%), respectively. Conclusions: COS can better help patients with metastatic RCC rather than other RCC patients. Additionally, COS brings optimism for metastatic RCC patients with expected poorer prognosis psychologically. Frontiers Media S.A. 2019-07-15 /pmc/articles/PMC6644417/ /pubmed/31380266 http://dx.doi.org/10.3389/fonc.2019.00591 Text en Copyright © 2019 Shao, Wan, Abudurexiti, Wang, Zhu and Ye. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Shao, Ning Wan, Fangning Abudurexiti, Mierxiati Wang, Jun Zhu, Yao Ye, Dingwei Causes of Death and Conditional Survival of Renal Cell Carcinoma |
title | Causes of Death and Conditional Survival of Renal Cell Carcinoma |
title_full | Causes of Death and Conditional Survival of Renal Cell Carcinoma |
title_fullStr | Causes of Death and Conditional Survival of Renal Cell Carcinoma |
title_full_unstemmed | Causes of Death and Conditional Survival of Renal Cell Carcinoma |
title_short | Causes of Death and Conditional Survival of Renal Cell Carcinoma |
title_sort | causes of death and conditional survival of renal cell carcinoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644417/ https://www.ncbi.nlm.nih.gov/pubmed/31380266 http://dx.doi.org/10.3389/fonc.2019.00591 |
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