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Causes of Death and Conditional Survival of Renal Cell Carcinoma

Background: As conditional survival could provide more relevant prognostic information at each follow-up time, the present study aimed to assess conditional overall survival (COS) based on two cohorts and assess the risks of death due to renal cell carcinoma (RCC) vs. other causes. Methods: The Fuda...

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Autores principales: Shao, Ning, Wan, Fangning, Abudurexiti, Mierxiati, Wang, Jun, Zhu, Yao, Ye, Dingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644417/
https://www.ncbi.nlm.nih.gov/pubmed/31380266
http://dx.doi.org/10.3389/fonc.2019.00591
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author Shao, Ning
Wan, Fangning
Abudurexiti, Mierxiati
Wang, Jun
Zhu, Yao
Ye, Dingwei
author_facet Shao, Ning
Wan, Fangning
Abudurexiti, Mierxiati
Wang, Jun
Zhu, Yao
Ye, Dingwei
author_sort Shao, Ning
collection PubMed
description Background: As conditional survival could provide more relevant prognostic information at each follow-up time, the present study aimed to assess conditional overall survival (COS) based on two cohorts and assess the risks of death due to renal cell carcinoma (RCC) vs. other causes. Methods: The Fudan University Shanghai Cancer Center (FUSCC) and Surveillance, Epidemiology, and End Results (SEER) database were used as the source of data for our analysis. COS and cancer-specific survival were evaluated using the Kaplan–Meier method. Results: A total of 90,927 patients (SEER cohort = 88,807, FUSCC cohort = 2,120) were enrolled. Our results suggest that hazards of other causes-related death were always higher than that of cancer-specific death in low-risk RCC patients, but lower in metastatic RCC patients. It exceeded that of cancer-specific death by 8 years in high-risk RCC patients. Only in metastatic RCC patients, the COS improved markedly with survivorship increasing. After surviving 1, 2, 3, 4, and 5 years, the 5 years COS increased by +10, +18, +23, +29, and 35% (the observed 5 years OS: 12%), respectively. Conclusions: COS can better help patients with metastatic RCC rather than other RCC patients. Additionally, COS brings optimism for metastatic RCC patients with expected poorer prognosis psychologically.
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spelling pubmed-66444172019-08-02 Causes of Death and Conditional Survival of Renal Cell Carcinoma Shao, Ning Wan, Fangning Abudurexiti, Mierxiati Wang, Jun Zhu, Yao Ye, Dingwei Front Oncol Oncology Background: As conditional survival could provide more relevant prognostic information at each follow-up time, the present study aimed to assess conditional overall survival (COS) based on two cohorts and assess the risks of death due to renal cell carcinoma (RCC) vs. other causes. Methods: The Fudan University Shanghai Cancer Center (FUSCC) and Surveillance, Epidemiology, and End Results (SEER) database were used as the source of data for our analysis. COS and cancer-specific survival were evaluated using the Kaplan–Meier method. Results: A total of 90,927 patients (SEER cohort = 88,807, FUSCC cohort = 2,120) were enrolled. Our results suggest that hazards of other causes-related death were always higher than that of cancer-specific death in low-risk RCC patients, but lower in metastatic RCC patients. It exceeded that of cancer-specific death by 8 years in high-risk RCC patients. Only in metastatic RCC patients, the COS improved markedly with survivorship increasing. After surviving 1, 2, 3, 4, and 5 years, the 5 years COS increased by +10, +18, +23, +29, and 35% (the observed 5 years OS: 12%), respectively. Conclusions: COS can better help patients with metastatic RCC rather than other RCC patients. Additionally, COS brings optimism for metastatic RCC patients with expected poorer prognosis psychologically. Frontiers Media S.A. 2019-07-15 /pmc/articles/PMC6644417/ /pubmed/31380266 http://dx.doi.org/10.3389/fonc.2019.00591 Text en Copyright © 2019 Shao, Wan, Abudurexiti, Wang, Zhu and Ye. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Shao, Ning
Wan, Fangning
Abudurexiti, Mierxiati
Wang, Jun
Zhu, Yao
Ye, Dingwei
Causes of Death and Conditional Survival of Renal Cell Carcinoma
title Causes of Death and Conditional Survival of Renal Cell Carcinoma
title_full Causes of Death and Conditional Survival of Renal Cell Carcinoma
title_fullStr Causes of Death and Conditional Survival of Renal Cell Carcinoma
title_full_unstemmed Causes of Death and Conditional Survival of Renal Cell Carcinoma
title_short Causes of Death and Conditional Survival of Renal Cell Carcinoma
title_sort causes of death and conditional survival of renal cell carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644417/
https://www.ncbi.nlm.nih.gov/pubmed/31380266
http://dx.doi.org/10.3389/fonc.2019.00591
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