Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode

[Image: see text] Design strategies for small molecular probes lay the foundation of numerous synthetic chemosensors. A water-soluble colorimetric calcium molecular probe inspired by the ionophore-based ion-selective optode is presented here with a tunable detection range (around micromolar at pH 7)...

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Autores principales: Zhu, Changyou, Huang, Manling, Lan, Jialing, Chung, Lung Wa, Li, Xin, Xie, Xiaojiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644788/
https://www.ncbi.nlm.nih.gov/pubmed/31457978
http://dx.doi.org/10.1021/acsomega.8b01813
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author Zhu, Changyou
Huang, Manling
Lan, Jialing
Chung, Lung Wa
Li, Xin
Xie, Xiaojiang
author_facet Zhu, Changyou
Huang, Manling
Lan, Jialing
Chung, Lung Wa
Li, Xin
Xie, Xiaojiang
author_sort Zhu, Changyou
collection PubMed
description [Image: see text] Design strategies for small molecular probes lay the foundation of numerous synthetic chemosensors. A water-soluble colorimetric calcium molecular probe inspired by the ionophore-based ion-selective optode is presented here with a tunable detection range (around micromolar at pH 7). The binding of Ca(2+) resulted in the deprotonation of the probe and thus a significant spectral change, mimicking the ion-exchange process in ion-selective optodes. The 1:1 exchange between Ca(2+) and H(+) was confirmed with Job’s plot. Computational studies revealed possible monomer and dimer forms of the probe–Ca(2+) complexes.
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spelling pubmed-66447882019-08-27 Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode Zhu, Changyou Huang, Manling Lan, Jialing Chung, Lung Wa Li, Xin Xie, Xiaojiang ACS Omega [Image: see text] Design strategies for small molecular probes lay the foundation of numerous synthetic chemosensors. A water-soluble colorimetric calcium molecular probe inspired by the ionophore-based ion-selective optode is presented here with a tunable detection range (around micromolar at pH 7). The binding of Ca(2+) resulted in the deprotonation of the probe and thus a significant spectral change, mimicking the ion-exchange process in ion-selective optodes. The 1:1 exchange between Ca(2+) and H(+) was confirmed with Job’s plot. Computational studies revealed possible monomer and dimer forms of the probe–Ca(2+) complexes. American Chemical Society 2018-10-03 /pmc/articles/PMC6644788/ /pubmed/31457978 http://dx.doi.org/10.1021/acsomega.8b01813 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Zhu, Changyou
Huang, Manling
Lan, Jialing
Chung, Lung Wa
Li, Xin
Xie, Xiaojiang
Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode
title Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode
title_full Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode
title_fullStr Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode
title_full_unstemmed Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode
title_short Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode
title_sort colorimetric calcium probe with comparison to an ion-selective optode
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644788/
https://www.ncbi.nlm.nih.gov/pubmed/31457978
http://dx.doi.org/10.1021/acsomega.8b01813
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