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Raman and Computational Study on the Adsorption of Xanthine on Silver Nanocolloids

[Image: see text] Xanthine is a nucleobase, deriving from adenine and guanine by deamination and oxidation processes, which may deposit in the human body causing diseases, similar to uric acid. Here, we have investigated the adsorption of xanthine on silver colloidal nanoparticles by means of surfac...

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Autores principales: Muniz-Miranda, Francesco, Pedone, Alfonso, Muniz-Miranda, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644810/
https://www.ncbi.nlm.nih.gov/pubmed/31458060
http://dx.doi.org/10.1021/acsomega.8b02174
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author Muniz-Miranda, Francesco
Pedone, Alfonso
Muniz-Miranda, Maurizio
author_facet Muniz-Miranda, Francesco
Pedone, Alfonso
Muniz-Miranda, Maurizio
author_sort Muniz-Miranda, Francesco
collection PubMed
description [Image: see text] Xanthine is a nucleobase, deriving from adenine and guanine by deamination and oxidation processes, which may deposit in the human body causing diseases, similar to uric acid. Here, we have investigated the adsorption of xanthine on silver colloidal nanoparticles by means of surface-enhanced Raman scattering (SERS) with an exciting radiation in the near-infrared spectral region, where interference due to fluorescence does not occur, along with density functional theory calculations of molecule/metal model systems. By adopting a combined experimental and computational approach, we have identified the “marker” SERS bands of xanthine and the tautomer that preferentially binds the silver particles, as well as the molecular group involved in the interaction with metal. This investigation allows using the FT-SERS spectroscopy for biosensory and diagnostic purposes in body fluids, detecting abnormal levels of xanthine, and preventing metabolic diseases.
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spelling pubmed-66448102019-08-27 Raman and Computational Study on the Adsorption of Xanthine on Silver Nanocolloids Muniz-Miranda, Francesco Pedone, Alfonso Muniz-Miranda, Maurizio ACS Omega [Image: see text] Xanthine is a nucleobase, deriving from adenine and guanine by deamination and oxidation processes, which may deposit in the human body causing diseases, similar to uric acid. Here, we have investigated the adsorption of xanthine on silver colloidal nanoparticles by means of surface-enhanced Raman scattering (SERS) with an exciting radiation in the near-infrared spectral region, where interference due to fluorescence does not occur, along with density functional theory calculations of molecule/metal model systems. By adopting a combined experimental and computational approach, we have identified the “marker” SERS bands of xanthine and the tautomer that preferentially binds the silver particles, as well as the molecular group involved in the interaction with metal. This investigation allows using the FT-SERS spectroscopy for biosensory and diagnostic purposes in body fluids, detecting abnormal levels of xanthine, and preventing metabolic diseases. American Chemical Society 2018-10-18 /pmc/articles/PMC6644810/ /pubmed/31458060 http://dx.doi.org/10.1021/acsomega.8b02174 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Muniz-Miranda, Francesco
Pedone, Alfonso
Muniz-Miranda, Maurizio
Raman and Computational Study on the Adsorption of Xanthine on Silver Nanocolloids
title Raman and Computational Study on the Adsorption of Xanthine on Silver Nanocolloids
title_full Raman and Computational Study on the Adsorption of Xanthine on Silver Nanocolloids
title_fullStr Raman and Computational Study on the Adsorption of Xanthine on Silver Nanocolloids
title_full_unstemmed Raman and Computational Study on the Adsorption of Xanthine on Silver Nanocolloids
title_short Raman and Computational Study on the Adsorption of Xanthine on Silver Nanocolloids
title_sort raman and computational study on the adsorption of xanthine on silver nanocolloids
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644810/
https://www.ncbi.nlm.nih.gov/pubmed/31458060
http://dx.doi.org/10.1021/acsomega.8b02174
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