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Effect of Supercritical CO(2) as Reaction Medium for Selective Hydrogenation of Acetophenone to 1-Phenylethanol

[Image: see text] 1-Phenylethanol (PhE) is widely employed in the pharmaceutical industry as an anti-inflammatory and analgesic drug, as well as in chewing gums and yogurts as a food additive. In this work, we have investigated the selective synthesis of 1-phenylethanol (PhE) by hydrogenation of ace...

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Detalles Bibliográficos
Autores principales: More, Santosh R., Yadav, Ganapati D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644883/
https://www.ncbi.nlm.nih.gov/pubmed/31458874
http://dx.doi.org/10.1021/acsomega.8b00001
Descripción
Sumario:[Image: see text] 1-Phenylethanol (PhE) is widely employed in the pharmaceutical industry as an anti-inflammatory and analgesic drug, as well as in chewing gums and yogurts as a food additive. In this work, we have investigated the selective synthesis of 1-phenylethanol (PhE) by hydrogenation of acetophenone using supercritical CO(2) as a solvent. Supercritical carbon dioxide (scCO(2)) replaces organic solvent because it is inexpensive, nontoxic, nonflammable, inert, and environmentally benign. Polyurea-based encapsulated mono- and bimetallic catalysts were synthesized and characterized using different characterization techniques. The effects of various reaction parameters, such as co-solvent, catalyst loading, hydrogen pressure, total scCO(2) pressure, and temperature, were studied to determine the reaction kinetics.