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Structure-Driven Discovery of α,γ-Diketoacid Inhibitors Against UL89 Herpesvirus Terminase

[Image: see text] Human cytomegalovirus (HCMV) is an opportunistic pathogen causing a variety of severe viral infections, including irreversible congenital disabilities. Nowadays, HCMV infection is treated by inhibiting the viral DNA polymerase. However, DNA polymerase inhibitors have several drawba...

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Detalles Bibliográficos
Autores principales:	Bongarzone, Salvatore, Nadal, Marta, Kaczmarska, Zuzanna, Machón, Cristina, Álvarez, Mercedes, Albericio, Fernando, Coll, Miquel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645139/ https://www.ncbi.nlm.nih.gov/pubmed/31458978 http://dx.doi.org/10.1021/acsomega.8b01472

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