Atom-Economical and Metal-Free Synthesis of Multisubstituted Furans from Intramolecular Aziridine Ring Opening

[Image: see text] Multisubstituted furans were prepared from dialkyl 2-(aziridin-2-ylmethylene)malonate and/or 1,3-dione through aziridine ring opening by the internal carbonyl oxygen with the assistance of BF(3)·OEt(2), followed by aromatization. This synthetic method is free from any metal and is...

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Autores principales: Yadav, Nagendra Nath, Jeong, Hyeonsu, Ha, Hyun-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645301/
https://www.ncbi.nlm.nih.gov/pubmed/31457314
http://dx.doi.org/10.1021/acsomega.7b01542
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author Yadav, Nagendra Nath
Jeong, Hyeonsu
Ha, Hyun-Joon
author_facet Yadav, Nagendra Nath
Jeong, Hyeonsu
Ha, Hyun-Joon
author_sort Yadav, Nagendra Nath
collection PubMed
description [Image: see text] Multisubstituted furans were prepared from dialkyl 2-(aziridin-2-ylmethylene)malonate and/or 1,3-dione through aziridine ring opening by the internal carbonyl oxygen with the assistance of BF(3)·OEt(2), followed by aromatization. This synthetic method is free from any metal and is atom-economical with all of the atoms in the starting material retained in the final product.
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spelling pubmed-66453012019-08-27 Atom-Economical and Metal-Free Synthesis of Multisubstituted Furans from Intramolecular Aziridine Ring Opening Yadav, Nagendra Nath Jeong, Hyeonsu Ha, Hyun-Joon ACS Omega [Image: see text] Multisubstituted furans were prepared from dialkyl 2-(aziridin-2-ylmethylene)malonate and/or 1,3-dione through aziridine ring opening by the internal carbonyl oxygen with the assistance of BF(3)·OEt(2), followed by aromatization. This synthetic method is free from any metal and is atom-economical with all of the atoms in the starting material retained in the final product. American Chemical Society 2017-11-01 /pmc/articles/PMC6645301/ /pubmed/31457314 http://dx.doi.org/10.1021/acsomega.7b01542 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Yadav, Nagendra Nath
Jeong, Hyeonsu
Ha, Hyun-Joon
Atom-Economical and Metal-Free Synthesis of Multisubstituted Furans from Intramolecular Aziridine Ring Opening
title Atom-Economical and Metal-Free Synthesis of Multisubstituted Furans from Intramolecular Aziridine Ring Opening
title_full Atom-Economical and Metal-Free Synthesis of Multisubstituted Furans from Intramolecular Aziridine Ring Opening
title_fullStr Atom-Economical and Metal-Free Synthesis of Multisubstituted Furans from Intramolecular Aziridine Ring Opening
title_full_unstemmed Atom-Economical and Metal-Free Synthesis of Multisubstituted Furans from Intramolecular Aziridine Ring Opening
title_short Atom-Economical and Metal-Free Synthesis of Multisubstituted Furans from Intramolecular Aziridine Ring Opening
title_sort atom-economical and metal-free synthesis of multisubstituted furans from intramolecular aziridine ring opening
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645301/
https://www.ncbi.nlm.nih.gov/pubmed/31457314
http://dx.doi.org/10.1021/acsomega.7b01542
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AT hahyunjoon atomeconomicalandmetalfreesynthesisofmultisubstitutedfuransfromintramolecularaziridineringopening

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