Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones

[Image: see text] An efficient tandem intermolecular one-pot aldol condensation/aza-addition reaction of 2-methyl-3-carbamoylpyrroles and aldehydes was developed for the synthesis of 2,3,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones. The reaction proceeded using only 3.0 equiv of ammonium aceta...

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Autores principales: Zhang, Zhiguo, Gao, Xiaolong, Wan, Yameng, Huang, Yuanyuan, Huang, Guoqing, Zhang, Guisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645481/
https://www.ncbi.nlm.nih.gov/pubmed/31457270
http://dx.doi.org/10.1021/acsomega.7b00626
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author Zhang, Zhiguo
Gao, Xiaolong
Wan, Yameng
Huang, Yuanyuan
Huang, Guoqing
Zhang, Guisheng
author_facet Zhang, Zhiguo
Gao, Xiaolong
Wan, Yameng
Huang, Yuanyuan
Huang, Guoqing
Zhang, Guisheng
author_sort Zhang, Zhiguo
collection PubMed
description [Image: see text] An efficient tandem intermolecular one-pot aldol condensation/aza-addition reaction of 2-methyl-3-carbamoylpyrroles and aldehydes was developed for the synthesis of 2,3,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones. The reaction proceeded using only 3.0 equiv of ammonium acetate promoter in green solvent poly(ethylene glycol)-400 at 100 °C to afford a series of pyrrolo[3,2-c]pyridinone derivatives in good to excellent yields.
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spelling pubmed-66454812019-08-27 Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones Zhang, Zhiguo Gao, Xiaolong Wan, Yameng Huang, Yuanyuan Huang, Guoqing Zhang, Guisheng ACS Omega [Image: see text] An efficient tandem intermolecular one-pot aldol condensation/aza-addition reaction of 2-methyl-3-carbamoylpyrroles and aldehydes was developed for the synthesis of 2,3,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones. The reaction proceeded using only 3.0 equiv of ammonium acetate promoter in green solvent poly(ethylene glycol)-400 at 100 °C to afford a series of pyrrolo[3,2-c]pyridinone derivatives in good to excellent yields. American Chemical Society 2017-10-17 /pmc/articles/PMC6645481/ /pubmed/31457270 http://dx.doi.org/10.1021/acsomega.7b00626 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Zhang, Zhiguo
Gao, Xiaolong
Wan, Yameng
Huang, Yuanyuan
Huang, Guoqing
Zhang, Guisheng
Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones
title Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones
title_full Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones
title_fullStr Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones
title_full_unstemmed Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones
title_short Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones
title_sort ammonium acetate-promoted one-pot tandem aldol condensation/aza-addition reactions: synthesis of 2,3,6,7-tetrahydro-1h-pyrrolo[3,2-c]pyridin-4(5h)-ones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645481/
https://www.ncbi.nlm.nih.gov/pubmed/31457270
http://dx.doi.org/10.1021/acsomega.7b00626
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