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PrP(C) knockdown by liposome-siRNA-peptide complexes (LSPCs) prolongs survival and normal behavior of prion-infected mice immunotolerant to treatment

Prion diseases are members of neurodegenerative protein misfolding diseases (NPMDs) that include Alzheimer’s, Parkinson’s and Huntington diseases, amyotrophic lateral sclerosis, tauopathies, traumatic brain injuries, and chronic traumatic encephalopathies. No known therapeutics extend survival or im...

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Detalles Bibliográficos
Autores principales:	Bender, Heather, Noyes, Noelle, Annis, Jessica L., Hitpas, Amanda, Mollnow, Luke, Croak, Kendra, Kane, Sarah, Wagner, Kaitlyn, Dow, Steven, Zabel, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645518/ https://www.ncbi.nlm.nih.gov/pubmed/31329627 http://dx.doi.org/10.1371/journal.pone.0219995

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