Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity

Apoptotic protease-activating factor 1 (Apaf-1) is a component of apoptosome, which regulates caspase-9 activity. In addition to apoptosis, Apaf-1 plays critical roles in the intra-S-phase checkpoint; therefore, impaired expression of Apaf-1 has been demonstrated in chemotherapy-resistant malignant...

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Detalles Bibliográficos
Autores principales: Ohta, Eri, Itoh, Masanori, Ueda, Masashi, Hida, Yoko, Wang, Miao-xing, Hayakawa-Ogura, Miki, Li, Shimo, Nishida, Emika, Ohta, Kazunori, Tana, Islam, Saiful, Nakagawa, Kiyomi, Sunayama, Tomomi, Chen, Huayue, Hirata, So, Endo, Masashi, Ohno, Yoya, Nakagawa, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645535/
https://www.ncbi.nlm.nih.gov/pubmed/31329620
http://dx.doi.org/10.1371/journal.pone.0219782

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