Cargando…

Synthesis and Characterization of Tunable, pH-Responsive Nanoparticle–Microgel Composites for Surface-Enhanced Raman Scattering Detection

[Image: see text] The synthesis of microgels with pH-tunable swelling leads to adjustable and pH-responsive substrates for surface-enhanced Raman scattering (SERS)-active nanoparticles (NPs). Sterically stabilized and cross-linked latexes were synthesized from random copolymers of styrene (S) and 2-...

Descripción completa

Detalles Bibliográficos
Autores principales: Curtis, Tyler, Taylor, Audrey K., Alden, Sasha E., Swanson, Christopher, Lo, Joelle, Knight, Liam, Silva, Alyson, Gates, Byron D., Emory, Steven R., Rider, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645554/
https://www.ncbi.nlm.nih.gov/pubmed/31459181
http://dx.doi.org/10.1021/acsomega.8b01561
_version_ 1783437486838513664
author Curtis, Tyler
Taylor, Audrey K.
Alden, Sasha E.
Swanson, Christopher
Lo, Joelle
Knight, Liam
Silva, Alyson
Gates, Byron D.
Emory, Steven R.
Rider, David A.
author_facet Curtis, Tyler
Taylor, Audrey K.
Alden, Sasha E.
Swanson, Christopher
Lo, Joelle
Knight, Liam
Silva, Alyson
Gates, Byron D.
Emory, Steven R.
Rider, David A.
author_sort Curtis, Tyler
collection PubMed
description [Image: see text] The synthesis of microgels with pH-tunable swelling leads to adjustable and pH-responsive substrates for surface-enhanced Raman scattering (SERS)-active nanoparticles (NPs). Sterically stabilized and cross-linked latexes were synthesized from random copolymers of styrene (S) and 2-vinylpyridine (2VP). The pH-dependent latex-to-microgel transition and swellability were tuned based on their hydrophobic-to-hydrophilic content established by the S/2VP ratio. The electrostatic loading of polystyrene/poly(2-vinylpyridine) microgels [PS(x)P2VP(y) (M)] with anions such as tetrachloroaurate (AuCl(4)(–)) and borate-capped Ag NPs was quantified. The PS(x)P2VP(y) (M) can load ∼0.3 equiv of AuCl(4)(–) and the subsequent photoreduction results in Au NP-loaded PS(x)P2VP(y) (M) with NPs located throughout the structure. Loading PS(x)P2VP(y) (M) with borate-capped Ag NPs produces PS(x)P2VP(y) (M) with NPs located on the surface of the microgels, where the Ag content is set by S/2VP. The pH-responsive SERS activity is also reported for these Ag NP-loaded microgels. Analytical enhancement factors for dissolved crystal violet are high (i.e., 10(9) to 10(10)) and are set by S/2VP. The Ag NP-loaded microgels with ∼80 wt % 2VP exhibited the most stable pH dependent response.
format Online
Article
Text
id pubmed-6645554
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-66455542019-08-27 Synthesis and Characterization of Tunable, pH-Responsive Nanoparticle–Microgel Composites for Surface-Enhanced Raman Scattering Detection Curtis, Tyler Taylor, Audrey K. Alden, Sasha E. Swanson, Christopher Lo, Joelle Knight, Liam Silva, Alyson Gates, Byron D. Emory, Steven R. Rider, David A. ACS Omega [Image: see text] The synthesis of microgels with pH-tunable swelling leads to adjustable and pH-responsive substrates for surface-enhanced Raman scattering (SERS)-active nanoparticles (NPs). Sterically stabilized and cross-linked latexes were synthesized from random copolymers of styrene (S) and 2-vinylpyridine (2VP). The pH-dependent latex-to-microgel transition and swellability were tuned based on their hydrophobic-to-hydrophilic content established by the S/2VP ratio. The electrostatic loading of polystyrene/poly(2-vinylpyridine) microgels [PS(x)P2VP(y) (M)] with anions such as tetrachloroaurate (AuCl(4)(–)) and borate-capped Ag NPs was quantified. The PS(x)P2VP(y) (M) can load ∼0.3 equiv of AuCl(4)(–) and the subsequent photoreduction results in Au NP-loaded PS(x)P2VP(y) (M) with NPs located throughout the structure. Loading PS(x)P2VP(y) (M) with borate-capped Ag NPs produces PS(x)P2VP(y) (M) with NPs located on the surface of the microgels, where the Ag content is set by S/2VP. The pH-responsive SERS activity is also reported for these Ag NP-loaded microgels. Analytical enhancement factors for dissolved crystal violet are high (i.e., 10(9) to 10(10)) and are set by S/2VP. The Ag NP-loaded microgels with ∼80 wt % 2VP exhibited the most stable pH dependent response. American Chemical Society 2018-09-05 /pmc/articles/PMC6645554/ /pubmed/31459181 http://dx.doi.org/10.1021/acsomega.8b01561 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Curtis, Tyler
Taylor, Audrey K.
Alden, Sasha E.
Swanson, Christopher
Lo, Joelle
Knight, Liam
Silva, Alyson
Gates, Byron D.
Emory, Steven R.
Rider, David A.
Synthesis and Characterization of Tunable, pH-Responsive Nanoparticle–Microgel Composites for Surface-Enhanced Raman Scattering Detection
title Synthesis and Characterization of Tunable, pH-Responsive Nanoparticle–Microgel Composites for Surface-Enhanced Raman Scattering Detection
title_full Synthesis and Characterization of Tunable, pH-Responsive Nanoparticle–Microgel Composites for Surface-Enhanced Raman Scattering Detection
title_fullStr Synthesis and Characterization of Tunable, pH-Responsive Nanoparticle–Microgel Composites for Surface-Enhanced Raman Scattering Detection
title_full_unstemmed Synthesis and Characterization of Tunable, pH-Responsive Nanoparticle–Microgel Composites for Surface-Enhanced Raman Scattering Detection
title_short Synthesis and Characterization of Tunable, pH-Responsive Nanoparticle–Microgel Composites for Surface-Enhanced Raman Scattering Detection
title_sort synthesis and characterization of tunable, ph-responsive nanoparticle–microgel composites for surface-enhanced raman scattering detection
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645554/
https://www.ncbi.nlm.nih.gov/pubmed/31459181
http://dx.doi.org/10.1021/acsomega.8b01561
work_keys_str_mv AT curtistyler synthesisandcharacterizationoftunablephresponsivenanoparticlemicrogelcompositesforsurfaceenhancedramanscatteringdetection
AT tayloraudreyk synthesisandcharacterizationoftunablephresponsivenanoparticlemicrogelcompositesforsurfaceenhancedramanscatteringdetection
AT aldensashae synthesisandcharacterizationoftunablephresponsivenanoparticlemicrogelcompositesforsurfaceenhancedramanscatteringdetection
AT swansonchristopher synthesisandcharacterizationoftunablephresponsivenanoparticlemicrogelcompositesforsurfaceenhancedramanscatteringdetection
AT lojoelle synthesisandcharacterizationoftunablephresponsivenanoparticlemicrogelcompositesforsurfaceenhancedramanscatteringdetection
AT knightliam synthesisandcharacterizationoftunablephresponsivenanoparticlemicrogelcompositesforsurfaceenhancedramanscatteringdetection
AT silvaalyson synthesisandcharacterizationoftunablephresponsivenanoparticlemicrogelcompositesforsurfaceenhancedramanscatteringdetection
AT gatesbyrond synthesisandcharacterizationoftunablephresponsivenanoparticlemicrogelcompositesforsurfaceenhancedramanscatteringdetection
AT emorystevenr synthesisandcharacterizationoftunablephresponsivenanoparticlemicrogelcompositesforsurfaceenhancedramanscatteringdetection
AT riderdavida synthesisandcharacterizationoftunablephresponsivenanoparticlemicrogelcompositesforsurfaceenhancedramanscatteringdetection