Normal B cell development and Pax5 expression in Thy28/ThyN1-deficient mice

Thy28, also known as ThyN1, is a highly conserved nuclear protein. We previously showed that in a chicken mature B cell line, Thy28 binds to the promoter of the gene encoding Pax5, a transcription factor essential for B cell development, and positively regulates its expression. Here, we generated a...

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Detalles Bibliográficos
Autores principales: Kitaura, Fusako, Yuno, Miyuki, Fujita, Toshitsugu, Wakana, Shigeharu, Ueda, Jun, Yamagata, Kazuo, Fujii, Hodaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645560/
https://www.ncbi.nlm.nih.gov/pubmed/31329649
http://dx.doi.org/10.1371/journal.pone.0220199
Descripción
Sumario:Thy28, also known as ThyN1, is a highly conserved nuclear protein. We previously showed that in a chicken mature B cell line, Thy28 binds to the promoter of the gene encoding Pax5, a transcription factor essential for B cell development, and positively regulates its expression. Here, we generated a Thy28-deficient mouse line to analyze its potential role in B cell development in mice. Thy28-deficient mice showed normal development of B cells, and the expression of Pax5 was comparable between wild-type and Thy28-deficient primary B cells. Thus, species-specific mechanisms regulate Pax5 expression and B cell development.

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