Cargando…

Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention

Visual attention enables us to prioritise behaviourally relevant visual information while ignoring distraction. The neural networks supporting attention are modulated by two catecholamines, dopamine and noradrenaline. The current study investigated the effects of single nucleotide polymorphisms in t...

Descripción completa

Detalles Bibliográficos
Autores principales: Shalev, Nir, Vangkilde, Signe, Neville, Matt J., Tunbridge, Elizabeth M., Nobre, Anna C., Chechlacz, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645579/
https://www.ncbi.nlm.nih.gov/pubmed/31195057
http://dx.doi.org/10.1016/j.neuroscience.2019.05.068
_version_ 1783437492687470592
author Shalev, Nir
Vangkilde, Signe
Neville, Matt J.
Tunbridge, Elizabeth M.
Nobre, Anna C.
Chechlacz, Magdalena
author_facet Shalev, Nir
Vangkilde, Signe
Neville, Matt J.
Tunbridge, Elizabeth M.
Nobre, Anna C.
Chechlacz, Magdalena
author_sort Shalev, Nir
collection PubMed
description Visual attention enables us to prioritise behaviourally relevant visual information while ignoring distraction. The neural networks supporting attention are modulated by two catecholamines, dopamine and noradrenaline. The current study investigated the effects of single nucleotide polymorphisms in two catecholaminergic genes – COMT (Val(158)Met) and DBH (444 G/A) – on individual differences in attention functions. Participants (n = 125) were recruited from the Oxford Biobank by genotype-based recall. They were tested on a continuous performance task (sustained attention), a Go/No-Go task (response inhibition), and a task assessing attentional selection in accordance with the Theory of Visual Attention (TVA). We found a significant effect of DBH genotype status on the capacity to maintain attention over time (sustained attention) as measured by the continuous performance task. Furthermore, we demonstrated a significant association between COMT genotype status and effective threshold of visual perception in attentional selection as estimated based on the TVA task performance. No other group differences in attention function were found with respect to the studied genotypes. Overall, our findings provide novel experimental evidence that: (i) dopaminergic and noradrenergic genotypes have dissociable effects on visual attention; (ii) either insufficient or excessive catecholaminergic activity may have equally detrimental effects on sustained attention.
format Online
Article
Text
id pubmed-6645579
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Elsevier Science
record_format MEDLINE/PubMed
spelling pubmed-66455792019-08-01 Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention Shalev, Nir Vangkilde, Signe Neville, Matt J. Tunbridge, Elizabeth M. Nobre, Anna C. Chechlacz, Magdalena Neuroscience Article Visual attention enables us to prioritise behaviourally relevant visual information while ignoring distraction. The neural networks supporting attention are modulated by two catecholamines, dopamine and noradrenaline. The current study investigated the effects of single nucleotide polymorphisms in two catecholaminergic genes – COMT (Val(158)Met) and DBH (444 G/A) – on individual differences in attention functions. Participants (n = 125) were recruited from the Oxford Biobank by genotype-based recall. They were tested on a continuous performance task (sustained attention), a Go/No-Go task (response inhibition), and a task assessing attentional selection in accordance with the Theory of Visual Attention (TVA). We found a significant effect of DBH genotype status on the capacity to maintain attention over time (sustained attention) as measured by the continuous performance task. Furthermore, we demonstrated a significant association between COMT genotype status and effective threshold of visual perception in attentional selection as estimated based on the TVA task performance. No other group differences in attention function were found with respect to the studied genotypes. Overall, our findings provide novel experimental evidence that: (i) dopaminergic and noradrenergic genotypes have dissociable effects on visual attention; (ii) either insufficient or excessive catecholaminergic activity may have equally detrimental effects on sustained attention. Elsevier Science 2019-08-01 /pmc/articles/PMC6645579/ /pubmed/31195057 http://dx.doi.org/10.1016/j.neuroscience.2019.05.068 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shalev, Nir
Vangkilde, Signe
Neville, Matt J.
Tunbridge, Elizabeth M.
Nobre, Anna C.
Chechlacz, Magdalena
Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention
title Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention
title_full Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention
title_fullStr Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention
title_full_unstemmed Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention
title_short Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention
title_sort dissociable catecholaminergic modulation of visual attention: differential effects of catechol-o-methyltransferase and dopamine beta-hydroxylase genes on visual attention
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645579/
https://www.ncbi.nlm.nih.gov/pubmed/31195057
http://dx.doi.org/10.1016/j.neuroscience.2019.05.068
work_keys_str_mv AT shalevnir dissociablecatecholaminergicmodulationofvisualattentiondifferentialeffectsofcatecholomethyltransferaseanddopaminebetahydroxylasegenesonvisualattention
AT vangkildesigne dissociablecatecholaminergicmodulationofvisualattentiondifferentialeffectsofcatecholomethyltransferaseanddopaminebetahydroxylasegenesonvisualattention
AT nevillemattj dissociablecatecholaminergicmodulationofvisualattentiondifferentialeffectsofcatecholomethyltransferaseanddopaminebetahydroxylasegenesonvisualattention
AT tunbridgeelizabethm dissociablecatecholaminergicmodulationofvisualattentiondifferentialeffectsofcatecholomethyltransferaseanddopaminebetahydroxylasegenesonvisualattention
AT nobreannac dissociablecatecholaminergicmodulationofvisualattentiondifferentialeffectsofcatecholomethyltransferaseanddopaminebetahydroxylasegenesonvisualattention
AT chechlaczmagdalena dissociablecatecholaminergicmodulationofvisualattentiondifferentialeffectsofcatecholomethyltransferaseanddopaminebetahydroxylasegenesonvisualattention