Thermodynamic study of the effect of ions on the interaction between dengue virus NS3 helicase and single stranded RNA

Dengue virus nonstructural protein 3 (NS3) fulfills multiple essential functions during the viral replication and constitutes a prominent drug target. NS3 is composed by a superfamily-2 RNA helicase domain joined to a serine protease domain. Quantitative fluorescence titrations employing a fluoresce...

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Detalles Bibliográficos
Autores principales: Cababie, Leila A., Incicco, J. Jeremías, González-Lebrero, Rodolfo M., Roman, Ernesto A., Gebhard, Leopoldo G., Gamarnik, Andrea V., Kaufman, Sergio B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646317/
https://www.ncbi.nlm.nih.gov/pubmed/31332207
http://dx.doi.org/10.1038/s41598-019-46741-4

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