Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral administration of acet...

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Detalles Bibliográficos
Autores principales: Antunes, Krist Helen, Fachi, José Luís, de Paula, Rosemeire, da Silva, Emanuelle Fraga, Pral, Laís Passariello, dos Santos, Adara Áurea, Dias, Greicy Brisa Malaquias, Vargas, José Eduardo, Puga, Renato, Mayer, Fabiana Quoos, Maito, Fábio, Zárate-Bladés, Carlos R., Ajami, Nadim J., Sant’Ana, Marcella Ramos, Candreva, Thamiris, Rodrigues, Hosana Gomes, Schmiele, Marcio, Silva Clerici, Maria Teresa Pedrosa, Proença-Modena, José Luiz, Vieira, Angélica Thomas, Mackay, Charles R., Mansur, Daniel, Caballero, Mauricio T., Marzec, Jacqui, Li, Jianying, Wang, Xuting, Bell, Douglas, Polack, Fernando P., Kleeberger, Steven R., Stein, Renato T., Vinolo, Marco Aurélio Ramirez, de Souza, Ana Paula Duarte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646332/
https://www.ncbi.nlm.nih.gov/pubmed/31332169
http://dx.doi.org/10.1038/s41467-019-11152-6

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