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X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline

X chromosome genetic variation has been proposed as a potential source of missing heritability for many complex diseases, including obesity. Currently, there is a lack of public available genetic datasets incorporating X chromosome genotype data. Although several X chromosome-specific statistics hav...

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Detalles Bibliográficos
Autores principales: Anguita-Ruiz, Augusto, Plaza-Diaz, Julio, Ruiz-Ojeda, Francisco Javier, Rupérez, Azahara I., Leis, Rosaura, Bueno, Gloria, Gil-Campos, Mercedes, Vázquez-Cobela, Rocío, Cañete, Ramón, Moreno, Luis A., Gil, Ángel, Aguilera, Concepción María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646348/
https://www.ncbi.nlm.nih.gov/pubmed/31332195
http://dx.doi.org/10.1038/s41597-019-0109-3
Descripción
Sumario:X chromosome genetic variation has been proposed as a potential source of missing heritability for many complex diseases, including obesity. Currently, there is a lack of public available genetic datasets incorporating X chromosome genotype data. Although several X chromosome-specific statistics have been developed, there is also a lack of readily available implementations for routine analysis. Here, we aimed: (1) to make public and describe a dataset incorporating phenotype and X chromosome genotype data from a cohort of 915 normal-weight, overweight and obese children, and (2) to deeply describe a whole implementation of the special X chromosome analytic process in genetics. Datasets and pipelines like this are crucial to get familiar with the steps in which X chromosome requires special attention and may raise awareness of the importance of this genomic region.