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X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline
X chromosome genetic variation has been proposed as a potential source of missing heritability for many complex diseases, including obesity. Currently, there is a lack of public available genetic datasets incorporating X chromosome genotype data. Although several X chromosome-specific statistics hav...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646348/ https://www.ncbi.nlm.nih.gov/pubmed/31332195 http://dx.doi.org/10.1038/s41597-019-0109-3 |
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author | Anguita-Ruiz, Augusto Plaza-Diaz, Julio Ruiz-Ojeda, Francisco Javier Rupérez, Azahara I. Leis, Rosaura Bueno, Gloria Gil-Campos, Mercedes Vázquez-Cobela, Rocío Cañete, Ramón Moreno, Luis A. Gil, Ángel Aguilera, Concepción María |
author_facet | Anguita-Ruiz, Augusto Plaza-Diaz, Julio Ruiz-Ojeda, Francisco Javier Rupérez, Azahara I. Leis, Rosaura Bueno, Gloria Gil-Campos, Mercedes Vázquez-Cobela, Rocío Cañete, Ramón Moreno, Luis A. Gil, Ángel Aguilera, Concepción María |
author_sort | Anguita-Ruiz, Augusto |
collection | PubMed |
description | X chromosome genetic variation has been proposed as a potential source of missing heritability for many complex diseases, including obesity. Currently, there is a lack of public available genetic datasets incorporating X chromosome genotype data. Although several X chromosome-specific statistics have been developed, there is also a lack of readily available implementations for routine analysis. Here, we aimed: (1) to make public and describe a dataset incorporating phenotype and X chromosome genotype data from a cohort of 915 normal-weight, overweight and obese children, and (2) to deeply describe a whole implementation of the special X chromosome analytic process in genetics. Datasets and pipelines like this are crucial to get familiar with the steps in which X chromosome requires special attention and may raise awareness of the importance of this genomic region. |
format | Online Article Text |
id | pubmed-6646348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-66463482019-07-23 X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline Anguita-Ruiz, Augusto Plaza-Diaz, Julio Ruiz-Ojeda, Francisco Javier Rupérez, Azahara I. Leis, Rosaura Bueno, Gloria Gil-Campos, Mercedes Vázquez-Cobela, Rocío Cañete, Ramón Moreno, Luis A. Gil, Ángel Aguilera, Concepción María Sci Data Data Descriptor X chromosome genetic variation has been proposed as a potential source of missing heritability for many complex diseases, including obesity. Currently, there is a lack of public available genetic datasets incorporating X chromosome genotype data. Although several X chromosome-specific statistics have been developed, there is also a lack of readily available implementations for routine analysis. Here, we aimed: (1) to make public and describe a dataset incorporating phenotype and X chromosome genotype data from a cohort of 915 normal-weight, overweight and obese children, and (2) to deeply describe a whole implementation of the special X chromosome analytic process in genetics. Datasets and pipelines like this are crucial to get familiar with the steps in which X chromosome requires special attention and may raise awareness of the importance of this genomic region. Nature Publishing Group UK 2019-07-22 /pmc/articles/PMC6646348/ /pubmed/31332195 http://dx.doi.org/10.1038/s41597-019-0109-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files associated with this article. |
spellingShingle | Data Descriptor Anguita-Ruiz, Augusto Plaza-Diaz, Julio Ruiz-Ojeda, Francisco Javier Rupérez, Azahara I. Leis, Rosaura Bueno, Gloria Gil-Campos, Mercedes Vázquez-Cobela, Rocío Cañete, Ramón Moreno, Luis A. Gil, Ángel Aguilera, Concepción María X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline |
title | X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline |
title_full | X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline |
title_fullStr | X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline |
title_full_unstemmed | X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline |
title_short | X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline |
title_sort | x chromosome genetic data in a spanish children cohort, dataset description and analysis pipeline |
topic | Data Descriptor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646348/ https://www.ncbi.nlm.nih.gov/pubmed/31332195 http://dx.doi.org/10.1038/s41597-019-0109-3 |
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