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The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn

TorsinA is an ER-resident AAA + ATPase, whose deletion of glutamate E303 results in the genetic neuromuscular disease primary dystonia. TorsinA is an unusual AAA + ATPase that needs an external activator. Also, it likely does not thread a peptide substrate through a narrow central channel, in contra...

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Detalles Bibliográficos
Autores principales:	Demircioglu, F. Esra, Zheng, Weili, McQuown, Alexander J., Maier, Nolan K., Watson, Nicki, Cheeseman, Iain M., Denic, Vladimir, Egelman, Edward H., Schwartz, Thomas U.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646356/ https://www.ncbi.nlm.nih.gov/pubmed/31332180 http://dx.doi.org/10.1038/s41467-019-11194-w

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