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Stretchable Low Impedance Electrodes for Bioelectronic Recording from Small Peripheral Nerves

Monitoring of bioelectric signals in peripheral sympathetic nerves of small animal models is crucial to gain understanding of how the autonomic nervous system controls specific body functions related to disease states. Advances in minimally-invasive electrodes for such recordings in chronic conditio...

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Autores principales: Decataldo, Francesco, Cramer, Tobias, Martelli, Davide, Gualandi, Isacco, Korim, Willian S., Yao, Song T., Tessarolo, Marta, Murgia, Mauro, Scavetta, Erika, Amici, Roberto, Fraboni, Beatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646361/
https://www.ncbi.nlm.nih.gov/pubmed/31332219
http://dx.doi.org/10.1038/s41598-019-46967-2
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author Decataldo, Francesco
Cramer, Tobias
Martelli, Davide
Gualandi, Isacco
Korim, Willian S.
Yao, Song T.
Tessarolo, Marta
Murgia, Mauro
Scavetta, Erika
Amici, Roberto
Fraboni, Beatrice
author_facet Decataldo, Francesco
Cramer, Tobias
Martelli, Davide
Gualandi, Isacco
Korim, Willian S.
Yao, Song T.
Tessarolo, Marta
Murgia, Mauro
Scavetta, Erika
Amici, Roberto
Fraboni, Beatrice
author_sort Decataldo, Francesco
collection PubMed
description Monitoring of bioelectric signals in peripheral sympathetic nerves of small animal models is crucial to gain understanding of how the autonomic nervous system controls specific body functions related to disease states. Advances in minimally-invasive electrodes for such recordings in chronic conditions rely on electrode materials that show low-impedance ionic/electronic interfaces and elastic mechanical properties compliant with the soft and fragile nerve strands. Here we report a highly stretchable low-impedance electrode realized by microcracked gold films as metallic conductors covered with stretchable conducting polymer composite to facilitate ion-to-electron exchange. The conducting polymer composite based on poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) obtains its adhesive, low-impedance properties by controlling thickness, plasticizer content and deposition conditions. Atomic Force Microscopy measurements under strain show that the optimized conducting polymer coating is compliant with the micro-crack mechanics of the underlying Au-layer, necessary to absorb the tensile deformation when the electrodes are stretched. We demonstrate functionality of the stretchable electrodes by performing high quality recordings of renal sympathetic nerve activity under chronic conditions in rats.
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spelling pubmed-66463612019-07-29 Stretchable Low Impedance Electrodes for Bioelectronic Recording from Small Peripheral Nerves Decataldo, Francesco Cramer, Tobias Martelli, Davide Gualandi, Isacco Korim, Willian S. Yao, Song T. Tessarolo, Marta Murgia, Mauro Scavetta, Erika Amici, Roberto Fraboni, Beatrice Sci Rep Article Monitoring of bioelectric signals in peripheral sympathetic nerves of small animal models is crucial to gain understanding of how the autonomic nervous system controls specific body functions related to disease states. Advances in minimally-invasive electrodes for such recordings in chronic conditions rely on electrode materials that show low-impedance ionic/electronic interfaces and elastic mechanical properties compliant with the soft and fragile nerve strands. Here we report a highly stretchable low-impedance electrode realized by microcracked gold films as metallic conductors covered with stretchable conducting polymer composite to facilitate ion-to-electron exchange. The conducting polymer composite based on poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) obtains its adhesive, low-impedance properties by controlling thickness, plasticizer content and deposition conditions. Atomic Force Microscopy measurements under strain show that the optimized conducting polymer coating is compliant with the micro-crack mechanics of the underlying Au-layer, necessary to absorb the tensile deformation when the electrodes are stretched. We demonstrate functionality of the stretchable electrodes by performing high quality recordings of renal sympathetic nerve activity under chronic conditions in rats. Nature Publishing Group UK 2019-07-22 /pmc/articles/PMC6646361/ /pubmed/31332219 http://dx.doi.org/10.1038/s41598-019-46967-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Decataldo, Francesco
Cramer, Tobias
Martelli, Davide
Gualandi, Isacco
Korim, Willian S.
Yao, Song T.
Tessarolo, Marta
Murgia, Mauro
Scavetta, Erika
Amici, Roberto
Fraboni, Beatrice
Stretchable Low Impedance Electrodes for Bioelectronic Recording from Small Peripheral Nerves
title Stretchable Low Impedance Electrodes for Bioelectronic Recording from Small Peripheral Nerves
title_full Stretchable Low Impedance Electrodes for Bioelectronic Recording from Small Peripheral Nerves
title_fullStr Stretchable Low Impedance Electrodes for Bioelectronic Recording from Small Peripheral Nerves
title_full_unstemmed Stretchable Low Impedance Electrodes for Bioelectronic Recording from Small Peripheral Nerves
title_short Stretchable Low Impedance Electrodes for Bioelectronic Recording from Small Peripheral Nerves
title_sort stretchable low impedance electrodes for bioelectronic recording from small peripheral nerves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646361/
https://www.ncbi.nlm.nih.gov/pubmed/31332219
http://dx.doi.org/10.1038/s41598-019-46967-2
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