A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors

Fenretinide is a synthetic retinoid characterized by anticancer activity in preclinical models and favorable toxicological profile, but also by a low bioavailability that hindered its clinical efficacy in former clinical trials. We developed a new formulation of fenretinide complexed with 2-hydroxyp...

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Detalles Bibliográficos
Autores principales: Orienti, Isabella, Francescangeli, Federica, De Angelis, Maria Laura, Fecchi, Katia, Bongiorno-Borbone, Lucilla, Signore, Michele, Peschiaroli, Angelo, Boe, Alessandra, Bruselles, Alessandro, Costantino, Angelita, Eramo, Adriana, Salvati, Valentina, Sette, Giovanni, Contavalli, Paola, Zolla, Lello, Oki, Toshihiko, Kitamura, Toshio, Spada, Massimo, Giuliani, Alessandro, Baiocchi, Marta, La Torre, Filippo, Melino, Gerry, Tartaglia, Marco, De Maria, Ruggero, Zeuner, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646369/
https://www.ncbi.nlm.nih.gov/pubmed/31332161
http://dx.doi.org/10.1038/s41419-019-1775-y

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