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High-fat diet intake induces depressive-like behavior in ovariectomized rats

This study tested the effects of ovariectomy, allied or not to high-fat feeding and estradiol replacement, on hormonal, metabolic and behavioral parameters, to explore the connection of obesity and depression after menopause. Wistar rats were either ovariectomized or sham-operated and fed with eithe...

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Autores principales: Boldarine, Valter T., Pedroso, Amanda P., Neto, Nelson I. P., Dornellas, Ana P. S., Nascimento, Cláudia M. O., Oyama, Lila M., Ribeiro, Eliane B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646372/
https://www.ncbi.nlm.nih.gov/pubmed/31332243
http://dx.doi.org/10.1038/s41598-019-47152-1
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author Boldarine, Valter T.
Pedroso, Amanda P.
Neto, Nelson I. P.
Dornellas, Ana P. S.
Nascimento, Cláudia M. O.
Oyama, Lila M.
Ribeiro, Eliane B.
author_facet Boldarine, Valter T.
Pedroso, Amanda P.
Neto, Nelson I. P.
Dornellas, Ana P. S.
Nascimento, Cláudia M. O.
Oyama, Lila M.
Ribeiro, Eliane B.
author_sort Boldarine, Valter T.
collection PubMed
description This study tested the effects of ovariectomy, allied or not to high-fat feeding and estradiol replacement, on hormonal, metabolic and behavioral parameters, to explore the connection of obesity and depression after menopause. Wistar rats were either ovariectomized or sham-operated and fed with either standard chow or lard-enriched diet for twelve weeks. Sub-groups of ovariectomized rats received estradiol replacement. Depressive-like behaviors were assessed by the forced swim test and locomotor activity was assessed by the elevated plus maze test. Ovariectomy alone increased body weight gain and feed efficiency and induced hyperleptinemia and glucose intolerance while it increased caloric intake and body adiposity only marginally. High-fat intake alone induced obesity and, in combination with ovariectomy, accentuated the ovariectomy-induced alterations. Estradiol replacement attenuated the hormonal alterations only in chow-fed rats. Ovariectomy combined with high-fat intake induced depressive-like behaviors, which were marginally attenuated by estradiol. Depressive-like behaviors were associated with metabolic and body composition parameters and with estrogen status. The data indicate that the vulnerability to develop depression after menopause is influenced by high-fat intake. It is suggested that weight management is a crucial issue in postmenopausal women, probably having a beneficial role in preventing the appearance of mental health problems.
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spelling pubmed-66463722019-07-29 High-fat diet intake induces depressive-like behavior in ovariectomized rats Boldarine, Valter T. Pedroso, Amanda P. Neto, Nelson I. P. Dornellas, Ana P. S. Nascimento, Cláudia M. O. Oyama, Lila M. Ribeiro, Eliane B. Sci Rep Article This study tested the effects of ovariectomy, allied or not to high-fat feeding and estradiol replacement, on hormonal, metabolic and behavioral parameters, to explore the connection of obesity and depression after menopause. Wistar rats were either ovariectomized or sham-operated and fed with either standard chow or lard-enriched diet for twelve weeks. Sub-groups of ovariectomized rats received estradiol replacement. Depressive-like behaviors were assessed by the forced swim test and locomotor activity was assessed by the elevated plus maze test. Ovariectomy alone increased body weight gain and feed efficiency and induced hyperleptinemia and glucose intolerance while it increased caloric intake and body adiposity only marginally. High-fat intake alone induced obesity and, in combination with ovariectomy, accentuated the ovariectomy-induced alterations. Estradiol replacement attenuated the hormonal alterations only in chow-fed rats. Ovariectomy combined with high-fat intake induced depressive-like behaviors, which were marginally attenuated by estradiol. Depressive-like behaviors were associated with metabolic and body composition parameters and with estrogen status. The data indicate that the vulnerability to develop depression after menopause is influenced by high-fat intake. It is suggested that weight management is a crucial issue in postmenopausal women, probably having a beneficial role in preventing the appearance of mental health problems. Nature Publishing Group UK 2019-07-22 /pmc/articles/PMC6646372/ /pubmed/31332243 http://dx.doi.org/10.1038/s41598-019-47152-1 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Boldarine, Valter T.
Pedroso, Amanda P.
Neto, Nelson I. P.
Dornellas, Ana P. S.
Nascimento, Cláudia M. O.
Oyama, Lila M.
Ribeiro, Eliane B.
High-fat diet intake induces depressive-like behavior in ovariectomized rats
title High-fat diet intake induces depressive-like behavior in ovariectomized rats
title_full High-fat diet intake induces depressive-like behavior in ovariectomized rats
title_fullStr High-fat diet intake induces depressive-like behavior in ovariectomized rats
title_full_unstemmed High-fat diet intake induces depressive-like behavior in ovariectomized rats
title_short High-fat diet intake induces depressive-like behavior in ovariectomized rats
title_sort high-fat diet intake induces depressive-like behavior in ovariectomized rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646372/
https://www.ncbi.nlm.nih.gov/pubmed/31332243
http://dx.doi.org/10.1038/s41598-019-47152-1
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