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Analysis of differences between (99m)Tc-MAA SPECT- and (90)Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy

BACKGROUND: The aim of this study was to compare predictive and post-treatment dosimetry and analyze the differences, investigating factors related to activity preparation and delivery, imaging modality used, and interventional radiology. METHODS: Twenty-three HCC patients treated by selective inter...

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Autores principales: Kafrouni, Marilyne, Allimant, Carole, Fourcade, Marjolaine, Vauclin, Sébastien, Guiu, Boris, Mariano-Goulart, Denis, Ben Bouallègue, Fayçal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646451/
https://www.ncbi.nlm.nih.gov/pubmed/31332585
http://dx.doi.org/10.1186/s13550-019-0533-6
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author Kafrouni, Marilyne
Allimant, Carole
Fourcade, Marjolaine
Vauclin, Sébastien
Guiu, Boris
Mariano-Goulart, Denis
Ben Bouallègue, Fayçal
author_facet Kafrouni, Marilyne
Allimant, Carole
Fourcade, Marjolaine
Vauclin, Sébastien
Guiu, Boris
Mariano-Goulart, Denis
Ben Bouallègue, Fayçal
author_sort Kafrouni, Marilyne
collection PubMed
description BACKGROUND: The aim of this study was to compare predictive and post-treatment dosimetry and analyze the differences, investigating factors related to activity preparation and delivery, imaging modality used, and interventional radiology. METHODS: Twenty-three HCC patients treated by selective internal radiation therapy with (90)Y glass microspheres were included in this study. Predictive and post-treatment dosimetry were calculated at the voxel level based on (99m)Tc-MAA SPECT/CT and (90)Y-microsphere PET/CT respectively. Dose distribution was analyzed through mean dose, metrics extracted from dose-volume histograms, and Dice similarity coefficients applied on isodoses. Reproducibility of the radiological gesture and its influence on dose deviation was evaluated. RESULTS: (90)Y delivered activity was lower than expected in 67% (16/24) of the cases mainly due to the residual activity. A mean deviation of − 6 ± 11% was observed between the delivered activity and the (90)Y PET’s FOV activity. In addition, a substantial difference of − 20 ± 8% was measured on (90)Y PET images between the activity in the liver and in the whole FOV. After normalization, (99m)Tc-MAA SPECT dosimetry was highly correlated and concordant with (90)Y-microsphere PET dosimetry for all dose metrics evaluated (ρ = 0.87, ρ(c) = 0.86, P = 3.10(−8) and ρ = 0.91, ρ(c) = 0.90, P = 7.10(−10) for tumor and normal liver mean dose respectively for example). Besides, mean tumor dose deviation was lower when the catheter position was identical than when it differed (16 Gy vs. 37 Gy, P = 0.007). Concordance between predictive and post-treatment dosimetry, evaluated with Dice similarity coefficients applied on isodoses, significantly correlated with the distance of the catheter position from artery bifurcation (P = 0.04, 0.0004, and 0.05, for 50 Gy, 100 Gy, and 150 Gy isodoses respectively). CONCLUSIONS: Discrepancies between planned activity and activity measured on (90)Y PET images were observed and seemed to be mainly related to clinical hazards and equipment issues. Predictive vs. post-treatment comparison of relative dose distributions between tumor and normal liver showed a good correlation and no significant difference highlighting the predictive value of (99m)Tc MAA SPECT/CT-based dosimetry. Besides, the reproducibility of catheter tip position appears critical in the agreement between predictive and actual dose distribution.
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spelling pubmed-66464512019-08-09 Analysis of differences between (99m)Tc-MAA SPECT- and (90)Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy Kafrouni, Marilyne Allimant, Carole Fourcade, Marjolaine Vauclin, Sébastien Guiu, Boris Mariano-Goulart, Denis Ben Bouallègue, Fayçal EJNMMI Res Original Research BACKGROUND: The aim of this study was to compare predictive and post-treatment dosimetry and analyze the differences, investigating factors related to activity preparation and delivery, imaging modality used, and interventional radiology. METHODS: Twenty-three HCC patients treated by selective internal radiation therapy with (90)Y glass microspheres were included in this study. Predictive and post-treatment dosimetry were calculated at the voxel level based on (99m)Tc-MAA SPECT/CT and (90)Y-microsphere PET/CT respectively. Dose distribution was analyzed through mean dose, metrics extracted from dose-volume histograms, and Dice similarity coefficients applied on isodoses. Reproducibility of the radiological gesture and its influence on dose deviation was evaluated. RESULTS: (90)Y delivered activity was lower than expected in 67% (16/24) of the cases mainly due to the residual activity. A mean deviation of − 6 ± 11% was observed between the delivered activity and the (90)Y PET’s FOV activity. In addition, a substantial difference of − 20 ± 8% was measured on (90)Y PET images between the activity in the liver and in the whole FOV. After normalization, (99m)Tc-MAA SPECT dosimetry was highly correlated and concordant with (90)Y-microsphere PET dosimetry for all dose metrics evaluated (ρ = 0.87, ρ(c) = 0.86, P = 3.10(−8) and ρ = 0.91, ρ(c) = 0.90, P = 7.10(−10) for tumor and normal liver mean dose respectively for example). Besides, mean tumor dose deviation was lower when the catheter position was identical than when it differed (16 Gy vs. 37 Gy, P = 0.007). Concordance between predictive and post-treatment dosimetry, evaluated with Dice similarity coefficients applied on isodoses, significantly correlated with the distance of the catheter position from artery bifurcation (P = 0.04, 0.0004, and 0.05, for 50 Gy, 100 Gy, and 150 Gy isodoses respectively). CONCLUSIONS: Discrepancies between planned activity and activity measured on (90)Y PET images were observed and seemed to be mainly related to clinical hazards and equipment issues. Predictive vs. post-treatment comparison of relative dose distributions between tumor and normal liver showed a good correlation and no significant difference highlighting the predictive value of (99m)Tc MAA SPECT/CT-based dosimetry. Besides, the reproducibility of catheter tip position appears critical in the agreement between predictive and actual dose distribution. Springer Berlin Heidelberg 2019-07-22 /pmc/articles/PMC6646451/ /pubmed/31332585 http://dx.doi.org/10.1186/s13550-019-0533-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Kafrouni, Marilyne
Allimant, Carole
Fourcade, Marjolaine
Vauclin, Sébastien
Guiu, Boris
Mariano-Goulart, Denis
Ben Bouallègue, Fayçal
Analysis of differences between (99m)Tc-MAA SPECT- and (90)Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy
title Analysis of differences between (99m)Tc-MAA SPECT- and (90)Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy
title_full Analysis of differences between (99m)Tc-MAA SPECT- and (90)Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy
title_fullStr Analysis of differences between (99m)Tc-MAA SPECT- and (90)Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy
title_full_unstemmed Analysis of differences between (99m)Tc-MAA SPECT- and (90)Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy
title_short Analysis of differences between (99m)Tc-MAA SPECT- and (90)Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy
title_sort analysis of differences between (99m)tc-maa spect- and (90)y-microsphere pet-based dosimetry for hepatocellular carcinoma selective internal radiation therapy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646451/
https://www.ncbi.nlm.nih.gov/pubmed/31332585
http://dx.doi.org/10.1186/s13550-019-0533-6
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