Cargando…

The Utilization of Freezing Steps in Mesenchymal Stromal Cell (MSC) Manufacturing: Potential Impact on Quality and Cell Functionality Attributes

Some recent reports suggest that cryopreserved and thawed mesenchymal stromal cells (MSCs) may have impaired functional properties as compared to freshly harvested MSCs from continuous cultures. A cryopreservation step in the manufacturing process brings important benefits, since it enables immediat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oja, Sofia, Kaartinen, Tanja, Ahti, Marja, Korhonen, Matti, Laitinen, Anita, Nystedt, Johanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646664/ https://www.ncbi.nlm.nih.gov/pubmed/31379832 http://dx.doi.org/10.3389/fimmu.2019.01627

Ejemplares similares

A robust and reproducible animal serum-free culture method for clinical-grade bone marrow-derived mesenchymal stromal cells
por: Laitinen, Anita, et al.
Publicado: (2015)

Immunomonitoring of MSC-Treated GvHD Patients Reveals Only Moderate Potential for Response Prediction but Indicates Treatment Safety
por: Keto, Joni, et al.
Publicado: (2018)

Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures
por: Oja, S., et al.
Publicado: (2018)

Osteogenic differentiation of mesenchymal stromal cells in two-dimensional and three-dimensional cultures without animal serum
por: Castrén, Eeva, et al.
Publicado: (2015)

HLA-DR expression in clinical-grade bone marrow-derived multipotent mesenchymal stromal cells: a two-site study
por: Grau-Vorster, Marta, et al.
Publicado: (2019)

Expression of neural cell adhesion molecule and polysialic acid in human bone marrow-derived mesenchymal stromal cells
por: Skog, Maria S., et al.
Publicado: (2016)

Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome
por: Fernández-Santos, Maria Eugenia, et al.
Publicado: (2022)

Expansion induced microRNA changes in bone marrow mesenchymal stromal cells reveals interplay between immune regulation and cell cycle
por: Kilpinen, Lotta, et al.
Publicado: (2016)

Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials
por: Lotfy, Ahmed, et al.
Publicado: (2023)

Mesenchymal stromal cells (MSC) from JAK2(+) myeloproliferative neoplasms differ from normal MSC and contribute to the maintenance of neoplastic hematopoiesis
por: Ramos, Teresa L., et al.
Publicado: (2017)

Induced Periosteum-Mimicking Membrane with Cell Barrier and Multipotential Stromal Cell (MSC) Homing Functionalities
por: Owston, Heather E., et al.
Publicado: (2020)

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications
por: Witwer, Kenneth W., et al.
Publicado: (2019)

Translational Animal Models Provide Insight Into Mesenchymal Stromal Cell (MSC) Secretome Therapy
por: Harman, Rebecca M., et al.
Publicado: (2021)

Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22
por: Hyvärinen, Kati, et al.
Publicado: (2018)

Establishment of a consensus definition for mesenchymal stromal cells (MSC) and reporting guidelines for clinical trials of MSC therapy: a modified Delphi study protocol
por: Renesme, Laurent, et al.
Publicado: (2021)

Procoagulant Activity of Umbilical Cord-Derived Mesenchymal Stromal Cells’ Extracellular Vesicles (MSC-EVs)
por: Wright, Adrienne, et al.
Publicado: (2023)

Editorial: Next generation MSC therapy manufacturing, potency and mechanism of action analysis
por: Chinnadurai, Raghavan, et al.
Publicado: (2023)

Clumping and Viability of Bone Marrow Derived Mesenchymal Stromal Cells under Different Preparation Procedures: A Flow Cytometry-Based In Vitro Study
por: Cui, Li-li, et al.
Publicado: (2016)

Interaction of MSC with tumor cells
por: Melzer, Catharina, et al.
Publicado: (2016)

Metabolism in Human Mesenchymal Stromal Cells: A Missing Link Between hMSC Biomanufacturing and Therapy?
por: Yuan, Xuegang, et al.
Publicado: (2019)

Characterization of immortalized human islet stromal cells reveals a MSC-like profile with pancreatic features
por: Villard, Orianne, et al.
Publicado: (2020)

Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicity
por: Johann, Pascal-David, et al.
Publicado: (2010)

Intracrine androgenic apparatus in human bone marrow stromal cells
por: Sillat, Tarvo, et al.
Publicado: (2009)

Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization
por: Mizukami, Amanda, et al.
Publicado: (2018)

Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC
por: Tamama, Kenichi, et al.
Publicado: (2010)

Correction to: Characterization of immortalized human islet stromal cells reveals a MSC-like profile with pancreatic features
por: Villard, Orianne, et al.
Publicado: (2020)

Assessment of Tumorigenic Potential in Mesenchymal-Stem/Stromal-Cell-Derived Small Extracellular Vesicles (MSC-sEV)
por: Tan, Thong Teck, et al.
Publicado: (2021)

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype
por: Waterman, Ruth S., et al.
Publicado: (2010)

Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients
por: Cheng, Rui-Juan, et al.
Publicado: (2019)

Translating Research into Clinical Scale Manufacturing of Mesenchymal Stromal Cells
por: Bieback, Karen, et al.
Publicado: (2011)

Bone-Marrow-Derived Mesenchymal Stromal Cells (MSC) from Diabetic and Nondiabetic Rats Have Similar Therapeutic Potentials
por: José, Vitória Santório de São, et al.
Publicado: (2017)

Effect of pro-inflammatory cytokine priming and storage temperature of the mesenchymal stromal cell (MSC) secretome on equine articular chondrocytes
por: Jammes, Manon, et al.
Publicado: (2023)

Human Mesenchymal Stromal Cell (MSC) Characteristics Vary Among Laboratories When Manufactured From the Same Source Material: A Report by the Cellular Therapy Team of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative
por: Stroncek, David F., et al.
Publicado: (2020)

Continuous Pharmaceutical Manufacturing
por: Korhonen, Ossi
Publicado: (2020)

Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvation
por: Nuschke, Austin, et al.
Publicado: (2016)

Long-Circulating and Fusogenic Liposomes Loaded with Paclitaxel and Doxorubicin: Effect of Excipient, Freezing, and Freeze-Drying on Quality Attributes
por: Roque, Marjorie, et al.
Publicado: (2022)

Freeze-Dried Mesenchymal Stem Cell-Secretome Pharmaceuticalization: Optimization of Formulation and Manufacturing Process Robustness
por: Mocchi, Michela, et al.
Publicado: (2021)

Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying
por: Nuytten, Gust, et al.
Publicado: (2021)

One-Step Derivation of Mesenchymal Stem Cell (MSC)-Like Cells from Human Pluripotent Stem Cells on a Fibrillar Collagen Coating
por: Liu, Yongxing, et al.
Publicado: (2012)

Successful Treatment of COVID-19 Patient on ECMO Using Mesenchymal Stromal Cells (MSC)-Derived Exosomes: A Case Report
por: Patel, S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ks9lhj6h9c4vk80f0cvap531mt