Decreased Expression of Negative Immune Checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T Follicular Helper Lineage Differentiation in GCA

Loss of immune checkpoint (IC) Programmed Death-1 (PD-1) and PD-Ligand1 (PD-L1) expression has been implicated in the immunopathology of Giant Cell Arteritis (GCA). The contribution of the negative immune checkpoint V-domain Immunoglobulin-containing suppressor of T cell activation (VISTA) to GCA pa...

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Detalles Bibliográficos
Autores principales: Hid Cadena, Rebeca, Reitsema, Rosanne D., Huitema, Minke G., van Sleen, Yannick, van der Geest, Kornelis S. M., Heeringa, Peter, Boots, Annemieke M. H., Abdulahad, Wayel H., Brouwer, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646729/
https://www.ncbi.nlm.nih.gov/pubmed/31379838
http://dx.doi.org/10.3389/fimmu.2019.01638

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