Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial

IMPORTANCE: Oligomeric amyloid-β peptide binds to cellular prion protein on the neuronal cell surface, activating intracellular fyn kinase to mediate synaptotoxicity and tauopathy. AZD0530 is an investigational kinase inhibitor specific for the Src family, including fyn, that has been repurposed for...

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Detalles Bibliográficos
Autores principales: van Dyck, Christopher H., Nygaard, Haakon B., Chen, Kewei, Donohue, Michael C., Raman, Rema, Rissman, Robert A., Brewer, James B., Koeppe, Robert A., Chow, Tiffany W., Rafii, Michael S., Gessert, Devon, Choi, Jiyoon, Turner, R. Scott, Kaye, Jeffrey A., Gale, Seth A., Reiman, Eric M., Aisen, Paul S., Strittmatter, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2019
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646979/
https://www.ncbi.nlm.nih.gov/pubmed/31329216
http://dx.doi.org/10.1001/jamaneurol.2019.2050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646979/
https://www.ncbi.nlm.nih.gov/pubmed/31329216
http://dx.doi.org/10.1001/jamaneurol.2019.2050

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