Comparison of Clinical Trial Changes in Primary Outcome and Reported Intervention Effect Size Between Trial Registration and Publication

IMPORTANCE: Primary outcome change could threaten the validity of a clinical trial; however, evidence about the consequences on the reported intervention effect size is unclear. OBJECTIVES: To examine the status of randomized clinical trials whose primary outcome changed between trial registration a...

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Detalles Bibliográficos
Autores principales: Chen, Tao, Li, Chao, Qin, Rui, Wang, Yang, Yu, Dahai, Dodd, James, Wang, Duolao, Cornelius, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2019
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646984/
https://www.ncbi.nlm.nih.gov/pubmed/31322690
http://dx.doi.org/10.1001/jamanetworkopen.2019.7242

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