Staphyloxanthin: a potential target for antivirulence therapy

Staphylococcus aureus is an important and common Gram-positive bacteria which causes clinical infections and food-poisoning cases. Therapeutic schedules for treatment of S. aureus infections are facing a challenge because of the emergence of multidrug resistance strains. It is urgent to find new ant...

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Detalles Bibliográficos
Autores principales: Xue, Lijun, Chen, Yang Yizhi, Yan, Zhiyun, Lu, Wei, Wan, Dong, Zhu, Huifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647007/
https://www.ncbi.nlm.nih.gov/pubmed/31410034
http://dx.doi.org/10.2147/IDR.S193649
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author Xue, Lijun
Chen, Yang Yizhi
Yan, Zhiyun
Lu, Wei
Wan, Dong
Zhu, Huifeng
author_facet Xue, Lijun
Chen, Yang Yizhi
Yan, Zhiyun
Lu, Wei
Wan, Dong
Zhu, Huifeng
author_sort Xue, Lijun
collection PubMed
description Staphylococcus aureus is an important and common Gram-positive bacteria which causes clinical infections and food-poisoning cases. Therapeutic schedules for treatment of S. aureus infections are facing a challenge because of the emergence of multidrug resistance strains. It is urgent to find new antiinfective drugs to control S. aureus infection. S. aureus strains are capable of producing the golden carotenoid pigment: staphyloxanthin, which acts as an important virulence factor and a potential target for antivirulence drug design. This review is aimed at presenting an updated overview of this golden carotenoid pigment of S. aureus from the biosynthesis of staphyloxanthin, its function, and the genes involved in pigment production to staphyloxanthin: a novel target for antivirulence therapy.
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spelling pubmed-66470072019-08-13 Staphyloxanthin: a potential target for antivirulence therapy Xue, Lijun Chen, Yang Yizhi Yan, Zhiyun Lu, Wei Wan, Dong Zhu, Huifeng Infect Drug Resist Review Staphylococcus aureus is an important and common Gram-positive bacteria which causes clinical infections and food-poisoning cases. Therapeutic schedules for treatment of S. aureus infections are facing a challenge because of the emergence of multidrug resistance strains. It is urgent to find new antiinfective drugs to control S. aureus infection. S. aureus strains are capable of producing the golden carotenoid pigment: staphyloxanthin, which acts as an important virulence factor and a potential target for antivirulence drug design. This review is aimed at presenting an updated overview of this golden carotenoid pigment of S. aureus from the biosynthesis of staphyloxanthin, its function, and the genes involved in pigment production to staphyloxanthin: a novel target for antivirulence therapy. Dove 2019-07-17 /pmc/articles/PMC6647007/ /pubmed/31410034 http://dx.doi.org/10.2147/IDR.S193649 Text en © 2019 Xue et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Xue, Lijun
Chen, Yang Yizhi
Yan, Zhiyun
Lu, Wei
Wan, Dong
Zhu, Huifeng
Staphyloxanthin: a potential target for antivirulence therapy
title Staphyloxanthin: a potential target for antivirulence therapy
title_full Staphyloxanthin: a potential target for antivirulence therapy
title_fullStr Staphyloxanthin: a potential target for antivirulence therapy
title_full_unstemmed Staphyloxanthin: a potential target for antivirulence therapy
title_short Staphyloxanthin: a potential target for antivirulence therapy
title_sort staphyloxanthin: a potential target for antivirulence therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647007/
https://www.ncbi.nlm.nih.gov/pubmed/31410034
http://dx.doi.org/10.2147/IDR.S193649
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