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Intravenous-to-oral antibiotic switch therapy: a cross-sectional study in critical care units

BACKGROUND: This study aimed to evaluate the oral switch (OS) stewardship intervention in the intensive care unit (ICU). METHODS: This was a retrospective study with a convenience sample in two Brazilian ICUs from different hospitals in patients with sepsis receiving antibiotic therapy. The stewards...

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Autores principales: Gasparetto, Juliano, Tuon, Felipe Francisco, dos Santos Oliveira, Dayana, Zequinao, Tiago, Pipolo, Gabriel Rammert, Ribeiro, Gabriel Velloso, Benincá, Paola Delai, Cruz, June Alisson Westarb, Moraes, Thyago Proenca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647098/
https://www.ncbi.nlm.nih.gov/pubmed/31331272
http://dx.doi.org/10.1186/s12879-019-4280-0
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author Gasparetto, Juliano
Tuon, Felipe Francisco
dos Santos Oliveira, Dayana
Zequinao, Tiago
Pipolo, Gabriel Rammert
Ribeiro, Gabriel Velloso
Benincá, Paola Delai
Cruz, June Alisson Westarb
Moraes, Thyago Proenca
author_facet Gasparetto, Juliano
Tuon, Felipe Francisco
dos Santos Oliveira, Dayana
Zequinao, Tiago
Pipolo, Gabriel Rammert
Ribeiro, Gabriel Velloso
Benincá, Paola Delai
Cruz, June Alisson Westarb
Moraes, Thyago Proenca
author_sort Gasparetto, Juliano
collection PubMed
description BACKGROUND: This study aimed to evaluate the oral switch (OS) stewardship intervention in the intensive care unit (ICU). METHODS: This was a retrospective study with a convenience sample in two Brazilian ICUs from different hospitals in patients with sepsis receiving antibiotic therapy. The stewardship intervention included OS in patients diagnosed with sepsis when clinical stability was achieved. The primary outcome was overall mortality. Other variables evaluated were as follows: cost of antimicrobial treatment, daily costs of intensive care, acute kidney injury, and length of stay. RESULTS: There was no difference in mortality between the OS and non-OS groups (p = 0.06). Length of stay in the ICU (p = 0.029) was shorter and acute kidney injury incidence (p = 0.032) and costs of antimicrobial therapy (p < 0.001) were lower in the OS group. CONCLUSION: OS stewardship programs in the ICU may be considered a safe strategy. Switch therapy reduced the cost and shortened the length of stay in ICUs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12879-019-4280-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-66470982019-07-31 Intravenous-to-oral antibiotic switch therapy: a cross-sectional study in critical care units Gasparetto, Juliano Tuon, Felipe Francisco dos Santos Oliveira, Dayana Zequinao, Tiago Pipolo, Gabriel Rammert Ribeiro, Gabriel Velloso Benincá, Paola Delai Cruz, June Alisson Westarb Moraes, Thyago Proenca BMC Infect Dis Research Article BACKGROUND: This study aimed to evaluate the oral switch (OS) stewardship intervention in the intensive care unit (ICU). METHODS: This was a retrospective study with a convenience sample in two Brazilian ICUs from different hospitals in patients with sepsis receiving antibiotic therapy. The stewardship intervention included OS in patients diagnosed with sepsis when clinical stability was achieved. The primary outcome was overall mortality. Other variables evaluated were as follows: cost of antimicrobial treatment, daily costs of intensive care, acute kidney injury, and length of stay. RESULTS: There was no difference in mortality between the OS and non-OS groups (p = 0.06). Length of stay in the ICU (p = 0.029) was shorter and acute kidney injury incidence (p = 0.032) and costs of antimicrobial therapy (p < 0.001) were lower in the OS group. CONCLUSION: OS stewardship programs in the ICU may be considered a safe strategy. Switch therapy reduced the cost and shortened the length of stay in ICUs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12879-019-4280-0) contains supplementary material, which is available to authorized users. BioMed Central 2019-07-22 /pmc/articles/PMC6647098/ /pubmed/31331272 http://dx.doi.org/10.1186/s12879-019-4280-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Gasparetto, Juliano
Tuon, Felipe Francisco
dos Santos Oliveira, Dayana
Zequinao, Tiago
Pipolo, Gabriel Rammert
Ribeiro, Gabriel Velloso
Benincá, Paola Delai
Cruz, June Alisson Westarb
Moraes, Thyago Proenca
Intravenous-to-oral antibiotic switch therapy: a cross-sectional study in critical care units
title Intravenous-to-oral antibiotic switch therapy: a cross-sectional study in critical care units
title_full Intravenous-to-oral antibiotic switch therapy: a cross-sectional study in critical care units
title_fullStr Intravenous-to-oral antibiotic switch therapy: a cross-sectional study in critical care units
title_full_unstemmed Intravenous-to-oral antibiotic switch therapy: a cross-sectional study in critical care units
title_short Intravenous-to-oral antibiotic switch therapy: a cross-sectional study in critical care units
title_sort intravenous-to-oral antibiotic switch therapy: a cross-sectional study in critical care units
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647098/
https://www.ncbi.nlm.nih.gov/pubmed/31331272
http://dx.doi.org/10.1186/s12879-019-4280-0
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