The canonical TGF-β/Smad signalling pathway is involved in PD-L1-induced primary resistance to EGFR-TKIs in EGFR-mutant non-small-cell lung cancer

BACKGROUND: Approximately 30% of patients with epidermal growth factor receptor (EGFR)-activating mutations have no response to EGFR-tyrosine kinase inhibitors (TKIs) (primary resistance). However, little is known about the molecular mechanism involved in primary resistance to EGFR-TKIs in EGFR-muta...

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Detalles Bibliográficos
Autores principales: Zhang, Yang, Zeng, Yuanyuan, Liu, Ting, Du, Wenwen, Zhu, Jianjie, Liu, Zeyi, Huang, Jian-an
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647099/
https://www.ncbi.nlm.nih.gov/pubmed/31331328
http://dx.doi.org/10.1186/s12931-019-1137-4

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