Why are so many MLL lysine methyltransferases required for normal mammalian development?

The mixed lineage leukemia (MLL) family of proteins became known initially for the leukemia link of its founding member. Over the decades, the MLL family has been recognized as an important class of histone H3 lysine 4 (H3K4) methyltransferases that control key aspects of normal cell physiology and...

Descripción completa

Detalles Bibliográficos
Autores principales: Crump, Nicholas T., Milne, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647185/
https://www.ncbi.nlm.nih.gov/pubmed/31098676
http://dx.doi.org/10.1007/s00018-019-03143-z
_version_ 1783437675222532096
author Crump, Nicholas T.
Milne, Thomas A.
author_facet Crump, Nicholas T.
Milne, Thomas A.
author_sort Crump, Nicholas T.
collection PubMed
description The mixed lineage leukemia (MLL) family of proteins became known initially for the leukemia link of its founding member. Over the decades, the MLL family has been recognized as an important class of histone H3 lysine 4 (H3K4) methyltransferases that control key aspects of normal cell physiology and development. Here, we provide a brief history of the discovery and study of this family of proteins. We address two main questions: why are there so many H3K4 methyltransferases in mammals; and is H3K4 methylation their key function?
format Online
Article
Text
id pubmed-6647185
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-66471852019-08-06 Why are so many MLL lysine methyltransferases required for normal mammalian development? Crump, Nicholas T. Milne, Thomas A. Cell Mol Life Sci Review The mixed lineage leukemia (MLL) family of proteins became known initially for the leukemia link of its founding member. Over the decades, the MLL family has been recognized as an important class of histone H3 lysine 4 (H3K4) methyltransferases that control key aspects of normal cell physiology and development. Here, we provide a brief history of the discovery and study of this family of proteins. We address two main questions: why are there so many H3K4 methyltransferases in mammals; and is H3K4 methylation their key function? Springer International Publishing 2019-05-16 2019 /pmc/articles/PMC6647185/ /pubmed/31098676 http://dx.doi.org/10.1007/s00018-019-03143-z Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Crump, Nicholas T.
Milne, Thomas A.
Why are so many MLL lysine methyltransferases required for normal mammalian development?
title Why are so many MLL lysine methyltransferases required for normal mammalian development?
title_full Why are so many MLL lysine methyltransferases required for normal mammalian development?
title_fullStr Why are so many MLL lysine methyltransferases required for normal mammalian development?
title_full_unstemmed Why are so many MLL lysine methyltransferases required for normal mammalian development?
title_short Why are so many MLL lysine methyltransferases required for normal mammalian development?
title_sort why are so many mll lysine methyltransferases required for normal mammalian development?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647185/
https://www.ncbi.nlm.nih.gov/pubmed/31098676
http://dx.doi.org/10.1007/s00018-019-03143-z
work_keys_str_mv AT crumpnicholast whyaresomanymlllysinemethyltransferasesrequiredfornormalmammaliandevelopment
AT milnethomasa whyaresomanymlllysinemethyltransferasesrequiredfornormalmammaliandevelopment

Ejemplares similares