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Growth pattern of uterine leiomyoma along pregnancy
BACKGROUND: Uterine leiomyomas are often discovered during early pregnancy and in most cases will have no effect on pregnancy outcomes. However, in rare cases uterine leiomyomas may lead to obstetric complications. The aim of the study was to evaluate rate of uterine leiomyoma growth in the 3 trimes...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647306/ https://www.ncbi.nlm.nih.gov/pubmed/31331317 http://dx.doi.org/10.1186/s12905-019-0803-5 |
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author | Chill, Henry Hillel Karavani, Gilad Rachmani, Talya Dior, Uri Tadmor, Ofer Shushan, Asher |
author_facet | Chill, Henry Hillel Karavani, Gilad Rachmani, Talya Dior, Uri Tadmor, Ofer Shushan, Asher |
author_sort | Chill, Henry Hillel |
collection | PubMed |
description | BACKGROUND: Uterine leiomyomas are often discovered during early pregnancy and in most cases will have no effect on pregnancy outcomes. However, in rare cases uterine leiomyomas may lead to obstetric complications. The aim of the study was to evaluate rate of uterine leiomyoma growth in the 3 trimesters of pregnancy. METHODS: We conducted a retrospective cohort study. Included were women who were diagnosed with uterine leiomyoma during pregnancy and had at least two sonographic measurements in different trimesters. Data regarding leiomyoma growth, recorded by ultrasound examination, during 1st 2nd and 3rd trimesters were collected from electronic patient records. RESULTS: Two-hundred forty-eight uterine leiomyomas were included in the study. Leiomyoma area increased substantially in size between the 1st and 2nd trimesters (54.5% ± 75.9%, p = .007) and to a lesser degree between the 2nd and 3rd trimesters (17.9% ± 59.7%, NS). Evaluation of the change in size throughout the pregnancy – between 1st and 3rd trimesters revealed a significant increase of 95.9% ± 191.3% (p < .001). There was no significant growth of the leiomyomas between the 2nd and 3rd trimesters. CONCLUSIONS: Uterine leiomyomas tend to grow substantially during the 1st trimester of pregnancy. This trend is attenuated later with minimal growth towards the end of gestation. |
format | Online Article Text |
id | pubmed-6647306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-66473062019-07-31 Growth pattern of uterine leiomyoma along pregnancy Chill, Henry Hillel Karavani, Gilad Rachmani, Talya Dior, Uri Tadmor, Ofer Shushan, Asher BMC Womens Health Research Article BACKGROUND: Uterine leiomyomas are often discovered during early pregnancy and in most cases will have no effect on pregnancy outcomes. However, in rare cases uterine leiomyomas may lead to obstetric complications. The aim of the study was to evaluate rate of uterine leiomyoma growth in the 3 trimesters of pregnancy. METHODS: We conducted a retrospective cohort study. Included were women who were diagnosed with uterine leiomyoma during pregnancy and had at least two sonographic measurements in different trimesters. Data regarding leiomyoma growth, recorded by ultrasound examination, during 1st 2nd and 3rd trimesters were collected from electronic patient records. RESULTS: Two-hundred forty-eight uterine leiomyomas were included in the study. Leiomyoma area increased substantially in size between the 1st and 2nd trimesters (54.5% ± 75.9%, p = .007) and to a lesser degree between the 2nd and 3rd trimesters (17.9% ± 59.7%, NS). Evaluation of the change in size throughout the pregnancy – between 1st and 3rd trimesters revealed a significant increase of 95.9% ± 191.3% (p < .001). There was no significant growth of the leiomyomas between the 2nd and 3rd trimesters. CONCLUSIONS: Uterine leiomyomas tend to grow substantially during the 1st trimester of pregnancy. This trend is attenuated later with minimal growth towards the end of gestation. BioMed Central 2019-07-22 /pmc/articles/PMC6647306/ /pubmed/31331317 http://dx.doi.org/10.1186/s12905-019-0803-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Chill, Henry Hillel Karavani, Gilad Rachmani, Talya Dior, Uri Tadmor, Ofer Shushan, Asher Growth pattern of uterine leiomyoma along pregnancy |
title | Growth pattern of uterine leiomyoma along pregnancy |
title_full | Growth pattern of uterine leiomyoma along pregnancy |
title_fullStr | Growth pattern of uterine leiomyoma along pregnancy |
title_full_unstemmed | Growth pattern of uterine leiomyoma along pregnancy |
title_short | Growth pattern of uterine leiomyoma along pregnancy |
title_sort | growth pattern of uterine leiomyoma along pregnancy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647306/ https://www.ncbi.nlm.nih.gov/pubmed/31331317 http://dx.doi.org/10.1186/s12905-019-0803-5 |
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